Mitochondrial calcium handling during ischemia-induced cell death in neurons

被引：67

作者：

Gouriou, Yves ^{[1
]}

Demaurex, Nicolas ^{[1
]}

Bijlenga, Philippe ^{[2
]}

De Marchi, Umberto ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Dept Clin Neurosci & Dermatol, CH-1211 Geneva, Switzerland

来源：

BIOCHIMIE | 2011年 / 93卷 / 12期

关键词：

Calcium signaling; Brain diseases; Cerebral ischemia; Apoptosis; Bioenergetics; PERMEABILITY TRANSITION PORE; WOLF-HIRSCHHORN-SYNDROME; GLOBAL BRAIN ISCHEMIA; CYCLOSPORINE-A; CYCLOPHILIN-D; BENZODIAZEPINE-RECEPTOR; REPERFUSION INJURY; POTASSIUM CHANNEL; OXIDATIVE STRESS; POSTISCHEMIC REPERFUSION;

D O I：

10.1016/j.biochi.2011.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria sense and shape cytosolic Ca2+ signals by taking up and subsequently releasing Ca2+ ions during physiological and pathological Ca2+ elevations. Sustained elevations in the mitochondrial matrix Ca2+ concentration are increasingly recognized as a defining feature of the intracellular cascade of lethal events that occur in neurons during cerebral ischemia. Here, we review the recently identified transport proteins that mediate the fluxes of Ca2+ across mitochondria and discuss the implication of the permeability transition pore in decoding the abnormally sustained mitochondrial Ca2+ elevations that occur during cerebral ischemia. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：2060 / 2067

页数：8

共 50 条

[21] PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy
Shi, Shuizhen
Ding, Chun
Zhu, Shuang
Xia, Fan
Buscho, Seth E.
Li, Shengguo
Motamedi, Massoud
Liu, Hua
Zhang, Wenbo
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (11)
[22] Estrogen can act via estrogen receptor α and β to protect hippocampal neurons against global ischemia-induced cell death
Miller, NR
Jover, T
Cohen, HW
Zukin, RS
Etgen, AM
ENDOCRINOLOGY, 2005, 146 (07) : 3070 - 3079
[23] PERK inhibition suppresses neovascularization and protects neurons during ischemia-induced retinopathy
Shi, Shuizhen
Zhu, Shuang
Ding, Chun
Xia, Fan
Buscho, Seth E.
Li, Shengguo
Motamedi, Massoud
Liu, Hua
Zhang, Wenbo
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
[24] Elevated Calcium Drives Ischemia-Induced Angiogenesis
Mulangala, Jocelyne
Akers, Emma
Solly, Emma L.
Bamhare, Panashe M.
Wilsdon, Laura A.
Tan, Joanne T.
Nicholls, Stephen J.
DiBartolo, Belinda A.
CIRCULATION, 2019, 140
[25] Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death
Agudo-Lopez, Alba
Miguel, Begona G.
Fernandez, Inmaculada
Martinez, Ana M.
FEBS LETTERS, 2011, 585 (01): : 99 - 103
[26] SK2 channels are neuroprotective for ischemia-induced neuronal cell death
Allen, Duane
Nakayama, Shin
Kuroiwa, Masayuki
Nakano, Takaaki
Palmateer, Julie
Kosaka, Yasuharu
Ballesteros, Carmen
Watanabe, Masahiko
Bond, Chris T.
Lujan, Rafael
Maylie, James
Adelman, John P.
Herson, Paco S.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (12): : 2302 - 2312
[27] Activated Protein C Rescues the Retina from Ischemia-Induced Cell Death
Du, Zhao-Jiang
Yamamoto, Takuhiro
Ueda, Tomoko
Suzuki, Mihoko
Tano, Yasuo
Kamei, Motohiro
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (02) : 987 - 993
[28] The antiapoptotic protein clusterin protects cardiomyocytes against ischemia-induced cell death
Krijnen, Paul A. J.
Niessen, Hans W. M.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (05): : H3223 - H3223
[29] The Extracellular Calcium-Sensing Receptor (CaSR) Promotes Ischemia-induced Injury in Hippocampal Neurons
Kim, Jong Youl
Cheng, Zhiqiang
Lee, Hokyou
Yenari, Midori A.
Chang, Wenhan
STROKE, 2010, 41 (04) : E286 - E286
[30] Ischemia-induced endothelial cell dysfunction
Keep, RF
Andjelkovic, AV
Stamatovic, SM
Shakui, P
Ennis, SR
Intracranial Pressure and Brain Monitoring XII, 2005, 95 : 399 - 402

← 1 2 3 4 5 →