Synthesis of β-lactam nucleoside chimera via Kinugasa reaction and evaluation of their antibacterial activity

被引：18
|
作者：
Basak, A [1 ]
Pal, R [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 08期
关键词：
beta-lactam; nucleoside; chimera; kinugasa reaction; antibacterial;
D O I：
10.1016/j.bmcl.2005.02.064
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several beta-lactam nucleoside chimeras 1 (cis) and 2 (trans) were synthesized from the corresponding N-propargyl nucleo-bases via Kinugasa reaction in moderate yields. Initial screening for antibacterial activity against ampicillin sensitive E coli showed weak activity for the uracil-beta-lactam chimera. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2015 / 2018
页数：4
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