Kinetic resolution of amino acid esters catalyzed by lipases

被引：0
|
作者：
Houng, JY [1 ]
Wu, ML [1 ]
Chen, ST [1 ]
机构：
[1] ACAD SINICA,INST BIOL CHEM,TAIPEI,TAIWAN
来源：
CHIRALITY | 1996年 / 8卷 / 06期
关键词：
lipase; resolution; amino acids; unnatural amino acids; enantioselectivity;
D O I：
10.1002/(SICI)1520-636X(1996)8:6<418::AID-CHIR2>3.0.CO;2-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Racemic amino acids were resolved by lipase via hydrolysis of their esters. Lipases (Pseudomonas lipase from Amano PS, Rhizopus lipase from Serva, and porcine pancrease lipase from Sigma) could selectively hydrolyze the L-amino acid esters in aqueous solution with high reactivities and selectivities. The effect of the structural changes in the ester moiety on the stereoselectivity of the lipases was also investigated using D,L-homophenylalanine as a model. Procedures were developed for the resolution of natural and unnatural amino acids. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码：418 / 422
页数：5
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