Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers

被引：41
|
作者：
Shearer, Jason [1 ]
Callan, Paige E. [1 ]
Tran, Thao [2 ]
Szalai, Veronika A. [2 ]
机构：
[1] Univ Nevada, Dept Chem, Reno, NV 89557 USA
[2] Univ Maryland Baltimore Cty, Dept Chem & Biochem, Baltimore, MD 21250 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 48期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
ALZHEIMERS-DISEASE; PEPTIDE; BINDING; PROTEIN; SITE;
D O I：
10.1039/c0cc02446e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The fatal neurological disorder Alzheimer's disease has been linked to soluble neurotoxic oligomers of amyloid-beta (A beta) peptides. Herein we demonstrate that Cu(1+) ligated within A beta(42) oligomers (Ab sequence: DAEFRHDSGYEVHHQKLVFFAE DVGSNKGAIIGLMVGGVVIA) possesses a highly dioxygen sensitive tetrahedral coordination geometry. The biological implications of these findings are discussed.
引用
收藏
页码：9137 / 9139
页数：3
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