Ligand-Free Nickel-Catalyzed Reductive Allylic Defluorinative Cross-Coupling of α-Trifluoromethyl Alkenes with Epoxides

被引：3
|
作者：
Lin, Zhiyang [1 ,2 ]
Lan, Yun [1 ,2 ]
Wang, Chuan [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[3] Chinese Acad Sci, Ctr Excellence Mol Synth, Hefei 230026, Anhui, Peoples R China
来源：
SYNLETT | 2021年 / 32卷 / 15期
基金：
中国国家自然科学基金;
关键词：
nickel catalysis; epoxides; difluoroalkenes; defluorination; ring opening; F BOND ACTIVATION; NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION; FUNCTIONALIZED GEM-DIFLUOROALKENES; DIFLUOROMETHYL 2-PYRIDYL SULFONE; C-F; DIAZO-COMPOUNDS; ORGANOLITHIUM REAGENTS; BIOLOGICAL-ACTIVITY; CONCISE SYNTHESIS; DIFLUOROOLEFINATION;
D O I：
10.1055/s-0040-1707170
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a reductive allylic defluorinative reaction of.-trifluoromethyl alkenes with terminal epoxides, which consists of an iodide-mediated regioselective ring opening and a nickel-catalyzed radical-type cross-coupling, providing diverse tertiary gemdifluorobishomoallylic alcohols in moderate to high yields. Notably, this reaction is conducted under mild conditions and requires no external ligand or proton donor.
引用
收藏
页码：1547 / 1550
页数：4
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