In vitro screening for drugs interacting with P-glycoprotein-mediated drug efflux using immortalized rat brain endothelial cells (RBE4)

被引:0
|
作者
Reichel, A [1 ]
Aleshaiker, A [1 ]
Begley, DJ [1 ]
Abbott, NJ [1 ]
机构
[1] UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHYSIOL GRP,LONDON WC2R 2LS,ENGLAND
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1996年 / 491P卷
关键词
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:P36 / P36
页数:1
相关论文
共 50 条
  • [31] A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles
    Bebawy, M
    Morris, MB
    Roufogalis, BD
    [J]. ANALYTICAL BIOCHEMISTRY, 1999, 268 (02) : 270 - 277
  • [32] Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice
    Bundgaard, Christoffer
    Jensen, Christian Jes Nyberg
    Garmer, Mats
    [J]. DRUG METABOLISM AND DISPOSITION, 2012, 40 (03) : 461 - 466
  • [33] IN-VIVO AND IN-VITRO EVIDENCE FOR ATP-DEPENDENCY OF P-GLYCOPROTEIN-MEDIATED EFFLUX OF DOXORUBICIN AT THE BLOOD-BRAIN-BARRIER
    OHNISHI, T
    TAMAI, I
    SAKANAKA, K
    SAKATA, A
    YAMASHIMA, T
    YAMASHITA, J
    TSUJI, A
    [J]. BIOCHEMICAL PHARMACOLOGY, 1995, 49 (10) : 1541 - 1544
  • [34] P-GLYCOPROTEIN AS THE DRUG EFFLUX PUMP IN PRIMARY CULTURED BOVINE BRAIN CAPILLARY ENDOTHELIAL-CELLS
    TSUJI, A
    TERASAKI, T
    TAKABATAKE, Y
    TENDA, Y
    TAMAI, I
    YAMASHIMA, T
    MORITANI, S
    TSURUO, T
    YAMASHITA, J
    [J]. LIFE SCIENCES, 1992, 51 (18) : 1427 - 1437
  • [35] Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells
    Yoo, Hye Hyun
    Lee, Mijin
    Chung, Hye Jin
    Lee, Sang Kyu
    Kim, Dong-Hyun
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (18) : 7620 - 7625
  • [36] Theoretical aspects of P-glycoprotein mediated drug efflux on the distribution volume of anaesthetic-related drugs in the brain
    Upton, RN
    [J]. ANAESTHESIA AND INTENSIVE CARE, 2002, 30 (02) : 183 - 191
  • [37] pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells
    Chen, Hsin-Hung
    Huang, Wen-Chia
    Chiang, Wen-Hsuan
    Liu, Te-I
    Shen, Ming-Yin
    Hsu, Yuan-Hung
    Lin, Sung-Chyr
    Chiu, Hsin-Cheng
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 10 : 5035 - 5048
  • [38] In Vitro Predictability of Drug-Drug Interaction Likelihood of P-Glycoprotein-Mediated Efflux of Dabigatran Etexilate Based on [I]2/IC50 Threshold
    Kishimoto, Wataru
    Ishiguro, Naoki
    Ludwig-Schwellinger, Eva
    Ebner, Thomas
    Schaefer, Olaf
    [J]. DRUG METABOLISM AND DISPOSITION, 2014, 42 (02) : 257 - 263
  • [39] P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4
    Hochman, JH
    Chiba, M
    Yamazaki, M
    Tang, CY
    Lin, JH
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2001, 298 (01): : 323 - 330
  • [40] High brain distribution of a new central nervous system drug candidate despite its P-glycoprotein-mediated efflux at the mouse blood-brain barrier
    Taccola, Camille
    Cartot-Cotton, Sylvaine
    Valente, Delphine
    Barneoud, Pascal
    Aubert, Catherine
    Boutet, Valerie
    Gallen, Fabienne
    Lochus, Murielle
    Nicolic, Sophie
    Dodacki, Agnes
    Smirnova, Maria
    Cisternino, Salvatore
    Decleves, Xavier
    Bourasset, Fanchon
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 117 : 68 - 79