The mechanisms through which childhood neglect leads to disordered eating behaviors are not well-understood, and these phenomena have been particularly understudied in men. The current study examined the associations between physical and emotional neglect occurring in childhood and 2 types of disordered eating symptoms (binge eating and drive for muscularity) among college men and women. Specifically, it was hypothesized that the relations between childhood physical and emotional neglect and eating disorder symptoms would be mediated by alexithymia. Participants (N = 1344) completed self-report measures through an online system. Four moderated mediation models were tested to examine our proposed mediation model in the context of potential gender differences. Consistent with prediction, our analyses revealed significant associations between childhood physical and emotional neglect and 2 types of disordered eating symptoms, and alexithymia mediated these relationships. Contrary to our hypothesis, gender moderated the relationship between alexithymia and binge eating, but not drive for muscularity. Childhood neglect, both physical and emotional, was associated with higher levels of binge eating in women, but not men. These findings suggest that the experience of neglect in early childhood may be related to certain types of eating disorder symptoms through its impact on the ability to identify, experience, and express one's own emotions.