Inhibition of metastasis by a dialysable factor in fetal bovine serum in B16 melanoma cells

被引：4

作者：

Ota, T ^{[1
]}

Maeda, M ^{[1
]}

Matsui, T ^{[1
]}

Kohno, H ^{[1
]}

Tanino, M ^{[1
]}

Odashima, S ^{[1
]}

机构：

[1] KANAZAWA MED UNIV,DEPT ORAL SURG,UCHINADA,ISHIKAWA 92002,JAPAN

来源：

CANCER LETTERS | 1996年 / 110卷 / 1-2期

关键词：

metastasis; fetal bovine serum; B16 melanoma cells;

D O I：

10.1016/S0304-3835(96)04496-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fetal bovine serum (FBS) supplemented to the culture medium inhibited the metastasis of B16BL6 melanoma cells in a dose-dependent manner. This metastasis-inhibiting activity was accompanied by growth-promoting activity, up to the concentration of 10% FBS, However, among the clones isolated from B16BL6 cells, there were clones in which FBS significantly inhibited the metastasis without promoting their growth. Dialysis (cutoff M.W, 8000 Da) removed the metastasis-inhibiting activity but not the growth-promoting activity from FBS. These results indicate that FBS has metastasis-inhibiting activity which is independent of growth-promoting activity, and that the metastasis-inhibiting activity is carried by molecules removed by dialysis.

引用

页码：201 / 205

页数：5

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