Two-photon fluorescent probes for intracellular free zinc ions in living tissue

被引：131
|
作者：
Kim, Hwan Myung [1 ]
Seo, Mun Sik [1 ]
An, Myoung Jin [1 ]
Hong, Jin Hee [2 ,3 ]
Tian, Yu Shun [1 ]
Choi, Joon Ho [2 ,3 ]
Kwon, Ohyun [4 ]
Lee, Kyoung J. [2 ,3 ]
Cho, Bong Rae [1 ]
机构：
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
[2] Korea Univ, Dept Phys, Seoul 136701, South Korea
[3] Korea Univ, Natl Creat Res Initiat Ctr Neurodynam, Seoul 136701, South Korea
[4] Samsung Adv Inst Technol, Seoul, South Korea
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 28期
关键词：
fluorescent probes; imaging agents; living tissue; two-photon microscopy; zinc;
D O I：
10.1002/anie.200800929
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24-to 52-fold two-photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80-150 mm without interference from other metal ions and the membrane-bound probes. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5167 / 5170
页数：4
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