Who is the boss in the Retinoblastoma family?: The point of view of Rb2/p130, the little brother

被引：0
|
作者：
Paggi, MG
Giordano, A
机构：
[1] Regina Elena Inst Canc Res, Lab Cell Metab & Pharmacokinet, Ctr Expt Res, I-00158 Rome, Italy
[2] Thomas Jefferson Univ, Jefferson Med Coll, Dept Pathol, Philadelphia, PA 19107 USA
[3] Thomas Jefferson Univ, Jefferson Med Coll, Dept Anat, Philadelphia, PA 19107 USA
[4] Thomas Jefferson Univ, Jefferson Med Coll, Dept Cell Biol, Philadelphia, PA 19107 USA
来源：
CANCER RESEARCH | 2001年 / 61卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RE itself and p107, After a brief analysis of the established structural and functional similarities among the three genes, the main purpose is to critically analyze present evidence whether Rb2/p130 shares the role of a tumor suppressor. Taking into account the well-proven growth suppressive properties of Rb2/p130 and p107, we discuss the analysis of mutated or deleted forms of Rb2/p130 found in a number of human cancers. Finally, we take into consideration the data provided by the targeted disruption of each RE family gene, alone or in combination, in the mouse model.
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页码：4651 / 4654
页数：4
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