Pentostatin for Treatment of Refractory Autoimmune Lymphoproliferative Syndrome

被引：8

作者：

Bajwa, Rajinder ^{[1
]}

Savelli, Stephanie ^{[2
]}

Gross, Thomas ^{[1
]}

机构：

[1] Nationwide Childrens Hosp, Dept Hematol Oncol BMT, Columbus, OH 43205 USA

[2] Childrens Hosp Med Ctr Akron, Akron, OH USA

来源：

PEDIATRIC BLOOD & CANCER | 2011年 / 57卷 / 02期

关键词：

autoimmune cytopenias; autoimmune lymphoproliferative syndrome; pentostatin; refractory ALPS; MYCOPHENOLATE-MOFETIL; SYNDROME ALPS;

D O I：

10.1002/pbc.23144

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autoimmune lymphoproliferative syndrome (ALPS), a disorder of programmed cell death, could be due to a congenital defect in the Fas signaling pathway or other pathways for apoptosis. Most cases present with lymphoproliferation and certain autoimmune features such as thrombocytopenia, neutropenia, and anemia are due to excessive production of antibodies by B lymphocytes. Majority of cases present within the first few years of life. We report a case of ALPS presenting at birth which was refractory to splenectomy and immunosuppressive therapy, but responded to pentostatin followed by hematopoietic stem cell transplantation (HSCT). Pediatr Blood Cancer. 2011;57:336-337. (C) 2011 Wiley-Liss, Inc.

引用

页码：336 / 337

页数：2

共 50 条

[21] A CASE OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME
Hollister, M.
Murray, M.
Casillas, A.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2011, 107 (05) : A79 - A79
[22] Autoimmune Lymphoproliferative Syndrome An Overview
Matson, Daniel R.
Yang, David T.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2020, 144 (02) : 245 - 251
[23] Spotlight on autoimmune lymphoproliferative syndrome
Ferrer, Elisa
Moral, Ma Angels
Bozzo, Jordi
DRUG NEWS & PERSPECTIVES, 2007, 20 (04) : 260 - 262
[24] Autoimmune lymphoproliferative syndrome.
Kancherla, V. S.
Ahmed, N.
Fischer, R.
Davis, J.
Niemela, J. E.
Eldin, K. W.
Noroski, L. M.
Redell, M. S.
Fleisher, T. A.
McClain, K. L.
Puck, J. M.
Paul, M. E.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2007, 98 (01) : A101 - A102
[25] Autoimmune lymphoproliferative syndrome.
ten Bosch, JV
Delabie, J
Boehler, T
Thielemans, K
Otten, J
BLOOD, 1998, 92 (10) : 231B - 231B
[26] Sirolimus is Effective in Treatment of Patients with Autoimmune Lymphoproliferative Syndrome (ALPS)
Deripapa, E. V.
Smirnova, I. N.
Varlamova, T. A.
Bobrynina, V. O.
Shvets, O. A.
Baidildina, D. D.
Fisiun, I. V.
Kalinina, I. I.
Maschan, M. A.
Shcherbina, A.
Maschan, A. A.
JOURNAL OF CLINICAL IMMUNOLOGY, 2014, 34 : S302 - S302
[27] Autoimmune Lymphoproliferative Syndrome or Autoimmune Lymphoproliferative Syndrome-Like? Why the Genetic Distinction Matters
Nguyen, Delena
Lopes, Joao Pedro Matias
CLINICAL IMMUNOLOGY, 2024, 262
[28] Autoimmune Lymphoproliferative Syndrome Masquerading as Posttransplant Lymphoproliferative Disorder
Jeffreys, Sarah M.
Levy, Rebecca A.
Crary, Shelley E.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2018, 40 (05) : E305 - E308
[29] Use of mycophenolate mofetil for chronic, refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome
Rao, VK
Dugan, F
Dale, JK
Davis, J
Tretler, J
Hurley, JK
Fleisher, T
Puck, J
Straus, SE
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 129 (04) : 534 - 538
[30] Successful treatment of autoimmune lymphoproliferative syndrome and refractory autoimmune thrombocytopenic purpura with a reduced intensity conditioning stem cell transplantation followed by donor lymphocyte infusion
Dimopoulou, M. N.
Gandhi, S.
Ghevaert, C.
Chakraverty, R.
Fielding, A.
Webster, D.
Mackinnon, S.
Kottaridis, P. D.
BONE MARROW TRANSPLANTATION, 2007, 40 (06) : 605 - 606

← 1 2 3 4 5 →