Oxidative two-way regiocontrolled coupling of 3-methoxycarbonylcatechol and indoles to arylindoles

被引:6
|
作者
Sawama, Yoshinari [1 ]
Kuwata, Shoko [2 ]
Mae, Miyu [1 ]
Udagawa, Taro [3 ]
Akai, Shuji [1 ]
Sajiki, Hironao [2 ]
机构
[1] Osaka Univ, Grad Sch Pharmaceut Sci, 1-6 Yamada Oka, Suita, Osaka 5650871, Japan
[2] Gifu Pharmaceut Univ, A Lab Organ Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan
[3] Gifu Univ, 1-1 Yanagido, Gifu 5011193, Japan
关键词
PHENOLS;
D O I
10.1039/d2cc04843d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
3-Methoxycarbonylcatechol effectively underwent two-way regiocontrolled coupling with indoles via an ortho-benzoquinone intermediate, resulting from phenyliodine(iii) diacetate oxidation, to generate 4-adducts or 5-adducts with or without BF3 center dot Et2O in a one-pot manner. DFT calculations confirmed the obtained regioselectivities.
引用
收藏
页码:12935 / 12938
页数:5
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