Niche regulation of muscle satellite cell self-renewal and differentiation

被引:359
|
作者
Kuang, Shihuan [1 ]
Gillespie, Mark A. [1 ,2 ]
Rudnicki, Michael A. [1 ,2 ]
机构
[1] Sprott Ctr Stem Cell Res, Ottawa Hlth Res Inst, Regenerat Med Program, Ottawa, ON K1H 8L6, Canada
[2] Univ Ottawa, Fac Med, Dept Cell & Mol Med, Ottawa, ON K1H 8M5, Canada
关键词
D O I
10.1016/j.stem.2007.12.012
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.
引用
收藏
页码:22 / 31
页数:10
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