Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs

被引：16
|
作者：
Ran, Xi [1 ,2 ]
Xiao, Chun-Hong [3 ]
Xiang, Gui-ming [1 ]
Ran, Xin-Ze [2 ]
机构：
[1] Third Mil Med Univ, Xinqiao Hosp, Dept Med Lab, Chongqing, Peoples R China
[2] Third Mil Med Univ, Coll Prevent Med, Inst Combined Injury PLA, State Key Lab Trauma Burns & Combined Injury, 30 Gaotanyan St, Chongqing 400038, Peoples R China
[3] Jinan Mil Command, Qingdao First Sanat, Qingdao, Peoples R China
来源：
CELLULAR REPROGRAMMING | 2017年 / 19卷 / 03期
关键词：
microRNAs; embryonic stem cells; regulation; self-renewal; differentiation; EXPRESSION PATTERNS; SMOOTH-MUSCLE; UP-REGULATION; MOUSE; PLURIPOTENCY; FAMILY; SOX2; IDENTIFICATION; PROLIFERATION; METHYLATION;
D O I：
10.1089/cell.2016.0048
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo. miRNAs are critical factors for the self-renewal and differentiation of ESCs. In this review, we will focus on the role of miRNAs in the self-renewal and directional differentiation of ESCs. We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs.
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页码：150 / 158
页数：9
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