Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs

被引：16
|
作者：
Ran, Xi [1 ,2 ]
Xiao, Chun-Hong [3 ]
Xiang, Gui-ming [1 ]
Ran, Xin-Ze [2 ]
机构：
[1] Third Mil Med Univ, Xinqiao Hosp, Dept Med Lab, Chongqing, Peoples R China
[2] Third Mil Med Univ, Coll Prevent Med, Inst Combined Injury PLA, State Key Lab Trauma Burns & Combined Injury, 30 Gaotanyan St, Chongqing 400038, Peoples R China
[3] Jinan Mil Command, Qingdao First Sanat, Qingdao, Peoples R China
来源：
CELLULAR REPROGRAMMING | 2017年 / 19卷 / 03期
关键词：
microRNAs; embryonic stem cells; regulation; self-renewal; differentiation; EXPRESSION PATTERNS; SMOOTH-MUSCLE; UP-REGULATION; MOUSE; PLURIPOTENCY; FAMILY; SOX2; IDENTIFICATION; PROLIFERATION; METHYLATION;
D O I：
10.1089/cell.2016.0048
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo. miRNAs are critical factors for the self-renewal and differentiation of ESCs. In this review, we will focus on the role of miRNAs in the self-renewal and directional differentiation of ESCs. We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs.
引用
收藏
页码：150 / 158
页数：9
相关论文
共 50 条
  • [31] Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor
    Hirai, Hiroyuki
    Karian, Peter
    Kikyo, Nobuaki
    BIOCHEMICAL JOURNAL, 2011, 438 : 11 - 23
  • [32] Regulation of Embryonic Stem Cell Self-Renewal and Pluripotency by Foxd3
    Liu, Ying
    Labosky, Patricia A.
    STEM CELLS, 2008, 26 (10) : 2475 - 2484
  • [33] The ground state of embryonic stem cell self-renewal
    Qi-Long Ying
    Jason Wray
    Jennifer Nichols
    Laura Batlle-Morera
    Bradley Doble
    James Woodgett
    Philip Cohen
    Austin Smith
    Nature, 2008, 453 : 519 - 523
  • [34] The genetic regulation of stem cell self-renewal
    Morrison, SJ
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 : 361A - 361A
  • [35] Threonine metabolism and embryonic stem cell self-renewal
    Chen, Guohua
    Wang, Jian
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2014, 17 (01): : 80 - 85
  • [36] Regulation of hematopoietic stem cell self-renewal
    Reya, T
    RECENT PROGRESS IN HORMONE RESEARCH, VOL 58: HUMAN GENOME AND ENDOCRINOLOGY, 2003, 58 : 283 - 295
  • [37] The ground state of embryonic stem cell self-renewal
    Ying, Qi-Long
    Wray, Jason
    Nichols, Jennifer
    Batlle-Morera, Laura
    Doble, Bradley
    Woodgett, James
    Cohen, Philip
    Smith, Austin
    NATURE, 2008, 453 (7194) : 519 - U5
  • [38] Transcriptional Regulation of Self-Renewal in Embryonic & Hematopoietic Stem Cells
    Reizis, Boris
    FASEB JOURNAL, 2009, 23
  • [39] Dissecting Embryonic Stem Cell Self-Renewal and Differentiation Commitment from Quantitative Models
    Hu, Rong
    Dai, Xianhua
    Dai, Zhiming
    Xiang, Qian
    Cai, Yanning
    DNA AND CELL BIOLOGY, 2016, 35 (10) : 607 - 621
  • [40] Nanoscale Topography and Chemistry Affect Embryonic Stem Cell Self-Renewal and Early Differentiation
    LaPointe, Vanessa L. S.
    Fernandes, Ana Tiago
    Bell, Nia C.
    Stellacci, Francesco
    Stevens, Molly M.
    ADVANCED HEALTHCARE MATERIALS, 2013, 2 (12) : 1644 - 1650
12345