Immunologic, Virologic, and Pharmacologic Characterization of the Female Upper Genital Tract in HIV-Infected Women

被引：7

作者：

Rahangdale, Lisa ^{[1
,2
]}

De Paris, Kristina ^{[2
,3
]}

Kashuba, Angela D. M. ^{[2
,4
]}

Nelson, Julie A. E. ^{[2
,3
]}

Cottrell, Mackenzie ^{[4
]}

Sykes, Craig ^{[4
]}

Emerson, Cindi ^{[2
,4
]}

Young, Steven L. ^{[1
]}

Stevens, Trenton ^{[5
]}

Patterson, Kristine B. ^{[2
,5
]}

Cohen, Myron S. ^{[2
,5
]}

机构：

[1] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Ctr AIDS Res, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[5] Univ Tennessee Hlth, Hlth Sci Ctr, Memphis, TN USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2015年 / 68卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV; female; endometrium; tenofovir; antiretroviral; inflammation; HUMAN-IMMUNODEFICIENCY-VIRUS; UTERINE EPITHELIAL-CELLS; LEUKOCYTE PROTEASE INHIBITOR; CD4(+) T-CELLS; VIRAL LOAD; INTRAVAGINAL INOCULATION; ANTIRETROVIRAL THERAPY; DOSE PHARMACOKINETICS; TRANSMISSION; TISSUE;

D O I：

10.1097/QAI.0000000000000480

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were >= 3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT.

引用

页码：420 / 424

页数：5

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