Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent

被引：4
|
作者：
Jeong, Lak Shin [1 ]
Lee, Jeong A. [1 ]
Moon, Hyung Ryong [2 ,3 ]
Kim, Hea Ok
Lee, Kang Man
Lee, Hyun Joo
Chun, Moon Woo [4 ]
机构：
[1] Ewha Womans Univ, Dept Pharm, Coll Pharm, Seoul 120750, South Korea
[2] Pusan Natl Univ, Coll Pharm, Pusan, South Korea
[3] Pusan Natl Univ, Res Inst Drug Dev, Pusan, South Korea
[4] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 6-7期
关键词：
apio carbocyclic nucleoside; stereoselective hydroxymethylation; ring-closing metathesis; Mitsunobu condensation; asymmetric synthesis;
D O I：
10.1080/15257770701493237
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.
引用
收藏
页码：721 / 724
页数：4
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