Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent

被引：4

作者：

Jeong, Lak Shin ^{[1
]}

Lee, Jeong A. ^{[1
]}

Moon, Hyung Ryong ^{[2
,3
]}

Kim, Hea Ok

Lee, Kang Man

Lee, Hyun Joo

Chun, Moon Woo ^{[4
]}

机构：

[1] Ewha Womans Univ, Dept Pharm, Coll Pharm, Seoul 120750, South Korea

[2] Pusan Natl Univ, Coll Pharm, Pusan, South Korea

[3] Pusan Natl Univ, Res Inst Drug Dev, Pusan, South Korea

[4] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 6-7期

关键词：

apio carbocyclic nucleoside; stereoselective hydroxymethylation; ring-closing metathesis; Mitsunobu condensation; asymmetric synthesis;

D O I：

10.1080/15257770701493237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.

引用

页码：721 / 724

页数：4

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