Growth hormone response to placebo, apomorphine and growth hormone releasing hormone in abstinent alcoholics and control subjects

被引：13
|
作者：
Wiesbeck, GA [1 ]
Mueller, T [1 ]
Wodarz, N [1 ]
Davids, E [1 ]
Kraus, T [1 ]
Thome, J [1 ]
Weijers, HG [1 ]
Boening, J [1 ]
机构：
[1] Univ Wurzburg, Dept Psychiat, Addict Res Grp, D-97080 Wurzburg, Germany
来源：
DRUG AND ALCOHOL DEPENDENCE | 1998年 / 52卷 / 01期
关键词：
alcoholism; apomorphine; human growth hormone; growth hormone releasing hormone; dopamine receptor sensitivity; pituitary function;
D O I：
10.1016/S0376-8716(98)00048-9
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Abstinent alcoholics and control subjects were challenged with placebo (saline), growth hormone releasing hormone (GHRH) and apomorphine (APO). While both groups did not differ in their growth hormone response (HGH) to placebo and GHRH, the alcoholics revealed a significant lower HGH response to dopamine receptor stimulation with APO. These findings provide no evidence that in abstinent alcoholics HGH blunting after dopamine receptor stimulation could be related to an alteration at the pituitary level but they give neuroendocrinological! support to the hypothesis of a lower dopamine receptor sensitivity in abstinent alcoholics. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：53 / 56
页数：4
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