Growth hormone response to placebo, apomorphine and growth hormone releasing hormone in abstinent alcoholics and control subjects

被引：13
|
作者：
Wiesbeck, GA [1 ]
Mueller, T [1 ]
Wodarz, N [1 ]
Davids, E [1 ]
Kraus, T [1 ]
Thome, J [1 ]
Weijers, HG [1 ]
Boening, J [1 ]
机构：
[1] Univ Wurzburg, Dept Psychiat, Addict Res Grp, D-97080 Wurzburg, Germany
来源：
DRUG AND ALCOHOL DEPENDENCE | 1998年 / 52卷 / 01期
关键词：
alcoholism; apomorphine; human growth hormone; growth hormone releasing hormone; dopamine receptor sensitivity; pituitary function;
D O I：
10.1016/S0376-8716(98)00048-9
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Abstinent alcoholics and control subjects were challenged with placebo (saline), growth hormone releasing hormone (GHRH) and apomorphine (APO). While both groups did not differ in their growth hormone response (HGH) to placebo and GHRH, the alcoholics revealed a significant lower HGH response to dopamine receptor stimulation with APO. These findings provide no evidence that in abstinent alcoholics HGH blunting after dopamine receptor stimulation could be related to an alteration at the pituitary level but they give neuroendocrinological! support to the hypothesis of a lower dopamine receptor sensitivity in abstinent alcoholics. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：53 / 56
页数：4
相关论文
共 50 条
  • [1] GROWTH-HORMONE RESPONSE TO GROWTH HORMONE-RELEASING HORMONE IN EARLY ABSTINENT ALCOHOLIC PATIENTS
    DEMARINIS, L
    MANCINI, A
    FIUMARA, C
    CONTE, G
    IACONA, T
    IANIRI, L
    ZEPPETELLI, E
    GOBBI, G
    TEMPESTA, E
    [J]. PSYCHONEUROENDOCRINOLOGY, 1993, 18 (07) : 475 - 483
  • [2] Lowering cortisol enhances growth hormone response to growth hormone releasing hormone in healthy subjects
    Thakore, JH
    Dinan, TG
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1996, 494P : P143 - P143
  • [3] LOWERING CORTISOL ENHANCES GROWTH-HORMONE RESPONSE TO GROWTH-HORMONE RELEASING HORMONE IN HEALTHY-SUBJECTS
    DINAN, TG
    THAKORE, J
    OKEANE, V
    [J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1994, 151 (03): : 413 - 416
  • [4] CIRCULATING IMMUNOREACTIVE GROWTH-HORMONE RELEASING HORMONE CONCENTRATIONS AND GROWTH-HORMONE RESPONSE TO GROWTH-HORMONE RELEASING HORMONE IN SHORT CHILDREN
    TAPANAINEN, PJ
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 1993, 152 (12) : 984 - 989
  • [5] GROWTH-HORMONE RESPONSE TO APOMORPHINE
    FERRIER, IN
    JOHNSTONE, EC
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 1987, 44 (01) : 93 - 93
  • [6] Effect of pyridostigmine on the thyroid-stimulating hormone response to thyrotropin-releasing hormone in abstinent alcoholics
    Coiro, V
    Vescovi, PP
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1997, 21 (07) : 1308 - 1311
  • [7] Low growth hormone response to growth hormone-releasing hormone in child depression
    Dahl, RE
    Birmaher, B
    Williamson, DE
    Dorn, L
    Perel, J
    Kaufman, J
    Brent, DA
    Axelson, DA
    Ryan, ND
    [J]. BIOLOGICAL PSYCHIATRY, 2000, 48 (10) : 981 - 988
  • [8] RESPONSE OF GROWTH-HORMONE TO GROWTH-HORMONE RELEASING HORMONE IN ADOLESCENTS WITH DIABETES
    GUERIN, A
    PFISTER, B
    OLIVER, C
    CONTEDEVOLX, B
    [J]. PRESSE MEDICALE, 1988, 17 (01): : 34 - 34
  • [9] GROWTH-HORMONE RESPONSE TO GROWTH HORMONE-RELEASING HORMONE AND CLONIDINE IN DEPRESSION
    GANN, H
    RIEMANN, D
    STOLL, S
    BERGER, M
    MULLER, WE
    [J]. BIOLOGICAL PSYCHIATRY, 1995, 38 (05) : 325 - 329
  • [10] GROWTH-HORMONE RESPONSE TO GROWTH-HORMONE RELEASING HORMONE IN DEPRESSION AND SCHIZOPHRENIA
    PEABODY, CA
    WARNER, MD
    MARKOFF, E
    HOFFMAN, AR
    WILSON, DM
    CSERNANSKY, JG
    [J]. PSYCHIATRY RESEARCH, 1990, 33 (03) : 269 - 276
12345