Copper-catalyzed three-component formal [3+1+2] annulations for the synthesis of 2-aminopyrimidines from O-acyl ketoximes

被引：6
|
作者：
Xu, Zhenhua [1 ]
Chen, Hongbiao [1 ]
Deng, Guo-Jun [1 ]
Huang, Huawen [1 ]
机构：
[1] Xiangtan Univ, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Coll Chem,Minist Educ, Xiangtan 411105, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 40期
基金：
中国国家自然科学基金;
关键词：
OXIME ACETATES; BIOLOGICAL-ACTIVITIES; FACILE SYNTHESIS; PYRIMIDINE; CYCLIZATION; INHIBITORS; PYRIDINES; ALDEHYDES; STRATEGY; CYCLOADDITION;
D O I：
10.1039/d1ob01582f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-based catalytic system has been developed to enable formal [3 + 1 + 2] annulations of ketoxime acetates, aldehydes, and cyanamides. This protocol offers a new strategy for the synthesis of highly substituted 2-aminopyrimidine compounds, and more importantly, pyrimidines have now been included in the N-heterocycle family constructed using O-acyl ketoximes as N-C-C synthons.
引用
收藏
页码：8706 / 8710
页数：5
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