Anti-Saccharomyces cerevisiae Antibodies in Rheumatoid Arthritis

被引：5
|
作者：
Melayah, Sarra [1 ,2 ]
Ghozzi, Mariem [1 ,2 ]
Jemni, Malek [1 ,2 ]
Sakly, Nabil [2 ,3 ]
Ghedira, Ibtissem [1 ,2 ]
Mankai, Amani [1 ,4 ]
机构：
[1] Farhat Hached Hosp, Lab Immunol, Sousse, Tunisia
[2] Monastir Univ, Fac Pharm, Dept Immunol, Monastir, Tunisia
[3] Fattouma Bourguiba Hosp, Lab Immunol, Monastir, Tunisia
[4] Tunis El Manar Univ, High Sch Sci & Tech Hlth, Tunis, Tunisia
来源：
LABORATORY MEDICINE | 2022年 / 53卷 / 06期
关键词：
anti-Saccharomyces cerevisiae antibodies; phosphopeptidomannan; rheumatoid arthritis; anti-CCP antibodies; rheumatoid factors; autoimmune disease; ANKYLOSING-SPONDYLITIS; CLASSIFICATION; DIAGNOSIS; MANNAN; LECTIN; ASCA; IGA;
D O I：
10.1093/labmed/lmac054
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective This study was conducted to evaluate the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with rheumatoid arthritis (RA). Methods Eighty-three RA patients with positive anti-cyclic citrullinated antibodies (anti-CCP) and 160 healthy blood donors were included in this study. ASCA IgG and IgA were assessed with enzyme-linked immunosorbent assay. Results The frequency of ASCA was significantly higher in RA patients than in healthy subjects (22.9% vs 3.7%, P < 10(-3)). Both ASCA IgG and ASCA IgA were significantly more frequent in RA patients than in the control group (20.5% vs 3.1%, P < 10(-3)and 9.6% vs 0.6%, P = .002, respectively). ASCA IgG and ASCA IgA levels were significantly higher in RA patients than in healthy subjects (7.8 +/- 8.4 U/mL vs 2.3 +/- 2.8 U/mL, P < 10(-6) and 6.2 +/- 10.9 U/mL vs 3.4 +/- 1.7 U/mL, P = .002, respectively). Conclusion A high frequency of ASCA IgG and ASCA IgA has been found in RA patients.
引用
收藏
页码：585 / 589
页数：5
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