Individual Differences in the Effects of Physical Activity on Cognitive Function in People with Mild to Moderate Dementia

被引:8
|
作者
Uijen, Iris L. [1 ,2 ]
Aaronson, Justine A. [2 ,3 ,4 ]
Karssemeijer, Esther G. A. [1 ,2 ]
Rikkert, Marcel G. M. Olde [1 ,2 ]
Kessels, Roy P. C. [2 ,4 ,5 ,6 ]
机构
[1] Radboud Univ Nijmegen, Dept Geriatr Med, Med Ctr, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Radboudumc Alzheimer Ctr, Med Ctr, Nijmegen, Netherlands
[3] OLVG Hosp, Amsterdam, Netherlands
[4] Radboud Univ Nijmegen, Dept Med Psychol, Med Ctr, Nijmegen, Netherlands
[5] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
[6] Vincent van Gogh Inst Psychiat, Venray, Netherlands
关键词
APOE epsilon 4; cognitive function; dementia; physical activity; reliable change index; RISK;
D O I
10.3233/JAD-190606
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The aim of this study was to investigate whether the effect of physical activity on cognitive function in persons with dementia is moderated by patient characteristics as Apolipoprotein E and dementia type. We included 101 individuals with dementia and calculated the reliable change index to determine the change in global cognition, executive function, episodic memory, working memory, and processing speed before and after a 12-week exercise training. We found a higher treatment-related benefit in episodic memory in persons with non-Alzheimer's disease compared to persons with Alzheimer's disease, and in executive function in individuals with better baseline cognitive function.
引用
收藏
页码:435 / 439
页数:5
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