Phase II two-arm study of tepotinib plus osimertinib in patients with EGFR-mutant NSCLC and acquired resistance to first-line osimertinib due to MET amplification: INSIGHT 2.

被引:2
|
作者
Zhu, Viola Weijia
Bestvina, Christine M.
Lopes, Gilberto
Hamm, John Turner
Johnson, Melissa Lynne
Lammers, Philip Edward
Le, Xiuning
Marathe, Omkar
Raez, Luis E.
Rao, Suman
Sabari, Joshua K.
Scheff, Ronald J.
Tapan, Umit
Thompson, Jonathan Robert
Karachaliou, Niki
Ellers-Lenz, Barbara
Brutlach, Sabine
Smit, Egbert F.
Wu, Yi-Long
机构
[1] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Orange, CA 92668 USA
[2] Univ Chicago, Med Ctr, Chicago, IL 60637 USA
[3] Univ Miami, Miller Sch Med, Miami, FL 33136 USA
[4] Norton Canc Inst PARENT, Louisville, KY USA
[5] Sarah Cannon Res Inst, Nashville, TN USA
[6] Baptist Canc Ctr, Memphis, TN USA
[7] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[8] Innovat Clin Res Inst, Anaheim, CA USA
[9] Mem Healthcare Syst, Hollywood, FL USA
[10] Medstar Franklin Sq Clin Res Ctr, Baltimore, MD USA
[11] NYU Langone Clin Canc Ctr, New York, NY USA
[12] Weill Cornell Med Coll, New York, NY USA
[13] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA
[14] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[15] Merck KGaA, Global Clin Dev, Darmstadt, Germany
[16] Merck KGaA, Dept Biostat, Darmstadt, Germany
[17] Merck KGaA, Darmstadt, Germany
[18] Netherlands Canc Inst, Amsterdam, Netherlands
[19] Guangdong Prov Peoples Hosp & Guangdong Acad Med, Guangdong Lung Canc Inst, Guangzhou, Peoples R China
关键词
D O I
10.1200/JCO.2021.39.15_suppl.TPS9136
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TPS9136
引用
下载
收藏
页数:3
相关论文
共 50 条
  • [21] Tepotinib plus gefitinib in patients with EGFR-mutant NSCLC with MET amplification (METamp): final analysis of INSIGHT
    Liam, Chong Kim
    Ahmad, Azura Rozila
    Hsia, Te-Chun
    Zhou, Jianying
    Kim, Dong-Wan
    Cheng, Ying
    Lu, Shun
    Shin, Sang Won
    Yang, James Chih-Hsin
    Zhang, Yiping
    Zhao, Jun
    Bruns, Rolf
    Johne, Andreas
    Wu, Yi-Long
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 3) : 177 - 177
  • [22] SAVANNAH: Phase II Trial of Osimertinib plus Savolitinib in EGFR-Mutant, MET-Driven Advanced NSCLC, Following Prior Osimertinib
    Ahn, M.
    Cantarini, M.
    Frewer, P.
    Hawkins, G.
    Peters, J.
    Howarth, P.
    Ahmed, G.
    Sahota, T.
    Hartmaier, R.
    Li-Sucholeiki, X.
    Oxnard, G.
    JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (10) : S415 - S416
  • [23] Assessment of early resistance mechanisms to first-line osimertinib in EGFR-mutant NSCLC using spatial transcriptomics
    de Garibay, G. Ruiz
    Roch, B.
    Garrido Lopez, P.
    Isla, D.
    Aguado, C.
    Callejo Perez, A.
    Marse Fabregat, R.
    Garcia Campelo, M. R.
    Blasco Cordellat, A.
    Sanchez Torres, J. M.
    Bernabe Caro, R.
    Juan Vidal, O. J.
    Carpeno, J. De Castro
    Franco, F. F.
    Ramos Garcia, I.
    Gomez Rueda, A.
    Conde Gallego, E.
    Ponce Aix, S.
    Paz-Ares, L.
    Zugazagoitia, J.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S1015 - S1016
  • [24] MARIPOSA: Randomized Phase 3 Study of First-line Amivantamab plus Lazertinib vs Osimertinib vs Lazertinib in EGFR-mutant NSCLC
    Shreeve, S. M.
    Martinez, M.
    Verheijen, R. B.
    Xie, J.
    Sun, T.
    Haddish-Berhane, N.
    Curtin, J. C.
    Karkera, J.
    Pang, D.
    Roshak, A.
    Knoblauch, R. E.
    Patel, K.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S620 - S621
  • [25] Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis
    Liam, Chong Kin
    Ahmad, Azura Rozila
    Hsia, Te-Chun
    Zhou, Jianying
    Kim, Dong-Wan
    Soo, Ross Andrew
    Cheng, Ying
    Lu, Shun
    Shin, Sang Won
    Yang, James Chih-Hsin
    Zhang, Yiping
    Zhao, Jun
    Berghoff, Karin
    Bruns, Rolf
    Johne, Andreas
    Wu, Yi-Long
    CLINICAL CANCER RESEARCH, 2023, 29 (10) : 1879 - 1886
  • [26] Phase II study of erlotinib plus onartuzumab as first-line treatment for patients with MET-positive and EGFR-mutant NSCLC
    Sakai, Hiroshi
    Kishi, Kazuma
    Seto, Takashi
    Kozuki, Toshiyuki
    Nishio, Makoto
    Imamura, Fumio
    Nokihara, Hiroshi
    Satouchi, Miyako
    Tahata, Takashi
    Nakagawa, Kazuhiko
    ANNALS OF ONCOLOGY, 2015, 26 : 82 - 82
  • [27] Treatment Patterns and Clinical Outcomes in Patients with EGFR-mutant NSCLC after Progression on First-Line Osimertinib
    Robinson, N. D.
    Zhan, P.
    Udelsman, B.
    Boffa, D. J.
    Goldberg, S. B.
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (11) : S364 - S364
  • [28] Detection of MET amplification (METamp) in patients with EGFR mutant (m) NSCLC after first-line (1L) osimertinib
    Yu, Helena Alexandra
    Kerr, Keith
    Rolfo, Christian Diego
    Fang, Jian
    Finocchiaro, Giovanna
    Wong, Kam-Hung
    Veillon, Remi
    Kato, Terufumi
    Yang, James Chih-Hsin
    Nadal, Ernest
    Raskin, Jo
    Le, Xiuning
    Karachaliou, Niki
    Ellers-Lenz, Barbara
    OBrate, Aurora
    Stroh, Christopher
    Piske, Nadine
    Boesler, Carsten
    Yang, Jinji
    Mazieres, Julien
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [29] Tepotinib plus osimertinib in patients with EGFR-mutated non-small-cell lung cancer with MET amplification following progression on first-line osimertinib (INSIGHT 2): a multicentre, open-label, phase 2 trial
    Wu, Yi-Long
    Guarneri, Valentina
    Voon, Pei Jye
    Lim, Boon Khaw
    Yang, Jin-Ji
    Wislez, Marie
    Huang, Cheng
    Liam, Chong Kin
    Mazieres, Julien
    Tho, Lye Mun
    Hayashi, Hidetoshi
    Nhung, Nguyen Viet
    Chia, Puey Ling
    de Marinis, Filippo
    Raskin, Jo
    Zhou, Qinghua
    Finocchiaro, Giovanna
    Le, Anh Tuan
    Wang, Jialei
    Dooms, Christophe
    Kato, Terufumi
    Nadal, Ernest
    Hin, How Soon
    Smit, Egbert F.
    Wermke, Martin
    Tan, Daniel
    Morise, Masahiro
    O'Brate, Aurora
    Adrian, Svenja
    Pfeiffer, Boris M.
    Stroh, Christopher
    Juraeva, Dilafruz
    Strotmann, Rainer
    Goteti, Kosalaram
    Berghoff, Karin
    Ellers-Lenz, Barbara
    Karachaliou, Niki
    Le, Xiuning
    Kim, Tae Min
    LANCET ONCOLOGY, 2024, 25 (08): : 989 - 1002
  • [30] The Role of Neutrophil-to-Lymphocyte Ratio in Advanced EGFR-Mutant NSCLC Patients Treated with First-Line Osimertinib
    Chen, Kuan-Chih
    Huang, Yen-Hsiang
    Hsu, Kuo-Hsuan
    Tseng, Jeng-Sen
    Chang, Gee-Chen
    Yang, Tsung-Ying
    ONCOTARGETS AND THERAPY, 2023, 16 : 317 - 326