Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

被引：6
|
作者：
Yang, Hong [1 ]
Liu, Yuexia [1 ]
Liu, Xuanchen [1 ]
Gu, Huihui [1 ]
Zhang, Jing [1 ]
Sun, Chao [1 ]
机构：
[1] Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China
来源：
STEM CELLS INTERNATIONAL | 2020年 / 2020卷
关键词：
HISTONE DEACETYLASE INHIBITION; GENE-EXPRESSION; PPAR-GAMMA; ADIPOGENIC DIFFERENTIATION; ADIPOSE-TISSUE; CHONDROGENIC DIFFERENTIATION; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; ADIPOCYTE DIFFERENTIATION; BINDING-PROTEIN;
D O I：
10.1155/2020/7618506
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Nowadays, the use of MSCs has attracted considerable attention in the global science and technology field, with the self-renewal and multidirectional differentiation potential for diabetes, obesity treatment, bone repair, nerve repair, myocardial repair, and so on. Epigenetics plays an important role in the regulation of mesenchymal stem cell differentiation, which has become a research hotspot in the medical field. This review focuses on the role of lysine acetylation modification on the determination of MSC differentiation direction. During this progress, the recruitment of lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) is the crux of transcriptional mechanisms in the dynamic regulation of key genes controlling MSC multidirectional differentiation.
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页数：11
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