Design and synthesis of novel antibacterial peptide-resin conjugates

被引：47
|
作者：
Cho, Won-Mi [1 ]
Joshi, Bishnu Prasad [1 ]
Cho, Hyeongjin [1 ]
Lee, Keun-Hyeung [1 ]
机构：
[1] Inha Univ, Dept Chem, Chem Bioorgan Lab, Inchon 402751, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 21期
关键词：
antibacterial activity; immobilization; beta-sheet; antimicrobial peptide; conjugation; resin;
D O I：
10.1016/j.bmcl.2007.08.056
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound beta-sheet antibacterial peptide. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5772 / 5776
页数：5
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