Design and synthesis of novel antibacterial peptide-resin conjugates

被引：47
|
作者：
Cho, Won-Mi [1 ]
Joshi, Bishnu Prasad [1 ]
Cho, Hyeongjin [1 ]
Lee, Keun-Hyeung [1 ]
机构：
[1] Inha Univ, Dept Chem, Chem Bioorgan Lab, Inchon 402751, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 21期
关键词：
antibacterial activity; immobilization; beta-sheet; antimicrobial peptide; conjugation; resin;
D O I：
10.1016/j.bmcl.2007.08.056
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound beta-sheet antibacterial peptide. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5772 / 5776
页数：5
相关论文
共 50 条
  • [1] Characterization of Antibacterial Activity and Synergistic Effect of Cationic Antibacterial Peptide-resin Conjugates
    Kim, Jeong Min
    Jang, Sujung
    Yang, Mi-Hwa
    Cho, Hyeongjin
    Lee, Keun-Hyeung
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 32 (11): : 3928 - 3932
  • [2] SYNTHESIS OF POLYAMIDE SUPPORTS FOR USE IN PEPTIDE-SYNTHESIS AND AS PEPTIDE-RESIN CONJUGATES FOR ANTIBODY-PRODUCTION
    KANDA, P
    KENNEDY, RC
    SPARROW, JT
    INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1991, 38 (04): : 385 - 391
  • [3] AUTOMATED PEPTIDE-RESIN DEPROTECTION CLEAVAGE BY A ROBOTIC WORKSTATION
    ZUCKERMANN, RN
    BANVILLE, SC
    PEPTIDE RESEARCH, 1992, 5 (03): : 169 - 174
  • [4] Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates
    Shi, Weiwei
    Chen, Feifei
    Zou, Xiangman
    Jiao, Shang
    Wang, Siqi
    Hu, Yu
    Lan, Lefu
    Tang, Feng
    Huang, Wei
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 45
  • [5] SOME NOVEL APPROACHES TO THE DESIGN AND SYNTHESIS OF PEPTIDE CATECHOLAMINE CONJUGATES
    VERLANDER, MS
    JACOBSON, KA
    ROSENKRANZ, RP
    MELMON, KL
    GOODMAN, M
    BIOPOLYMERS, 1983, 22 (01) : 531 - 545
  • [6] Design, Synthesis and Antibacterial Activity of Certain Novel Indole-glyoxylamide Conjugates
    Chellamuthu, Buvana
    Ramalingam, Suresh
    Haribabu, Yellina
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2022, 56 (04) : S682 - S694
  • [7] Design, synthesis and anticancer evaluation of novel oncolytic peptide-chlorambucil conjugates
    Yin, Hao
    Fu, Xing-Yan
    Gao, Han-Yu
    Ma, Yan-Nan
    Yao, Jing-Fang
    Du, Shan-Shan
    Qi, Yun-Kun
    Wang, Ke-Wei
    BIOORGANIC CHEMISTRY, 2023, 138
  • [8] Design and synthesis of peptide-macrolide conjugates
    Sumbatyan, N. V.
    Tashlitsky, V. N.
    Korshunova, G. A.
    JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 220 - 220
  • [9] CATALYTIC TRANSFER HYDROGENATION OF POLY(ACRYLOYLMORPHOLINE)-BASED PEPTIDE-RESIN ASSEMBLIES AND OF DERIVED PEPTIDE SEGMENTS
    EPTON, R
    HOCART, SJ
    MARR, G
    SMALL, PW
    POLYMER, 1982, 23 (11) : 1685 - 1687
  • [10] Facile synthesis of MDTPA and BMDTPA: Design and synthesis of novel DTPA-peptide conjugates for radiolabelling
    Surfraz, M.
    Blower, P.
    Biagini, S.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2007, 34 : S190 - S190
12345