Analysis of DFNA5's three distinct mutations by Apriori, Decision Tree

DFNA5's mutations are known as the reason of autosomal dominant non-syndromic hearing loss (ADNSHL). To date, DFNA5 has been mostly experimented by particular families DNA samples. By using three homo sapiens deafness sequences provided by ncbi, we investigated amino acid sequences in order to analyze relationships among mutants. We used apriori algorithm to find common amino acid which indicates a particular feature and decision tree C5.0 algorithm in order to discover the difference and what amino acid is likely to appear in each position. As a result, Leucine, Glycine, and Alanine were the most crucial amino acids to explain the relationship. This result made us to speculate that variant 2 and 3 are derived from variant 1. Hereby, our experiment suggests features of these mutants and arouses further research about how these amino acids affect the hearing-impaired.