Synthesis and studies on antidepressant activity of 2',4',6'-trihydroxychalcone derivatives

被引：22

作者：

Sui, Xin ^{[1
,2
]}

Quan, Ying-Chun ^{[2
]}

Chang, Yue ^{[2
]}

Zhang, Rui-Peng ^{[2
]}

Xu, Yin-Feng ^{[1
]}

Guan, Li-Ping ^{[1
]}

机构：

[1] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan City 316004, Zhejiang, Peoples R China

[2] Yanbian Univ, Coll Pharm, Yanji 133000, Jilin, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 07期

关键词：

2; 4; 6 '-Trihydroxychalcone derivatives; Synthesis; Antidepressant activity; BEHAVIORAL DESPAIR; ANIMAL-MODELS; FLAVONOIDS; CHALCONE;

D O I：

10.1007/s00044-011-9640-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, we synthesized a series of 2',4',6'-trihydroxychalcone derivatives and evaluated their antidepressant activities. The results of the nine compounds showed significantly reduced times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among the compounds, 2-bromo-2',4',6'-trihydroxychalcone (3h) was found to be the most potent, and it was observed that compound 3h at dose of 10, 20, and 40 mg/kg significantly reduced the duration of immobility times in the FST and TST in mice 30 min after treatment.

引用

页码：1290 / 1296

页数：7

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