Synthesis and studies on antidepressant activity of 2',4',6'-trihydroxychalcone derivatives

被引：22
|
作者：
Sui, Xin [1 ,2 ]
Quan, Ying-Chun [2 ]
Chang, Yue [2 ]
Zhang, Rui-Peng [2 ]
Xu, Yin-Feng [1 ]
Guan, Li-Ping [1 ]
机构：
[1] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan City 316004, Zhejiang, Peoples R China
[2] Yanbian Univ, Coll Pharm, Yanji 133000, Jilin, Peoples R China
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 07期
关键词：
2; 4; 6 '-Trihydroxychalcone derivatives; Synthesis; Antidepressant activity; BEHAVIORAL DESPAIR; ANIMAL-MODELS; FLAVONOIDS; CHALCONE;
D O I：
10.1007/s00044-011-9640-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, we synthesized a series of 2',4',6'-trihydroxychalcone derivatives and evaluated their antidepressant activities. The results of the nine compounds showed significantly reduced times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among the compounds, 2-bromo-2',4',6'-trihydroxychalcone (3h) was found to be the most potent, and it was observed that compound 3h at dose of 10, 20, and 40 mg/kg significantly reduced the duration of immobility times in the FST and TST in mice 30 min after treatment.
引用
收藏
页码：1290 / 1296
页数：7
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