Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

被引：36
|
作者：
Candiani, Gabriele
Frigerio, Massimo
Viani, Fiorenza
Verpelli, Chiara
Sala, Carlo
Chiamenti, Luca
Zaffaroni, Nadia
Folini, Marco
Sani, Monica
Panzeri, Walter
Zanda, Matteo
机构：
[1] C.N.R. - Istituto di Chimica del Riconoscimento Molecolare, Dipartimento C.M.I.C., Politecnico di Milano, 20131 Milan
[2] C.N.R. - Institute of Neuroscience, Cellular and Molecular Pharmacology, 20129 Milano
[3] Dipartimento di Oncologia Sperimentale, U.O. # 10, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Via Venezian
[4] C.N.R. -Istituto di Chimica del Riconoscimento Molecolare, KemoTech s.r.l., 20131 Milan
来源：
CHEMMEDCHEM | 2007年 / 2卷 / 03期
关键词：
Amphiphiles; DNA; Thiols; Transfection; Triazines;
D O I：
10.1002/cmdc.200600267
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(Chemical Equation Presented) The "Trojan Horse" trick works again. Conceptually new melamine-based cationic lipids show excellent transfection efficiency and low cytotoxicity in delivering a DNA plasmid payload to different types of cells, deceiving the natural mechanism of defense toward exogeneous DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：292 / 296
页数：5
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