Iron chelation of hetrombopag in aplastic anemia: a post hoc analysis of a phase II study

被引：7

作者：

Yang, Wenrui ^{[1
,2
]}

Zhao, Xin ^{[1
,2
]}

He, Guangsheng ^{[3
]}

Chang, Hong ^{[4
]}

Han, Bing ^{[5
]}

Gao, Sujun ^{[6
]}

Wang, Shunqing ^{[7
]}

Chen, Tong ^{[8
]}

Li, Fei ^{[9
]}

Wang, Yi ^{[10
]}

Ge, Xiaoyan ^{[11
]}

Fu, Rong ^{[12
]}

Ge, Zheng ^{[13
]}

Li, Yingmei ^{[14
]}

Liu, Hong ^{[15
]}

Liu, Xinjian ^{[16
]}

Miao, Miao ^{[17
]}

Zhang, Liansheng ^{[18
]}

Zhang, Fengkui ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, State Key Lab Expt Hematol, 288 Nanjing Rd, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Natl Clin Res Ctr Blood Dis, Haihe Lab Cell Ecosyst, 288 Nanjing Rd, Tianjin 300020, Peoples R China

[3] Jiangsu Prov Hosp, Nanjing, Peoples R China

[4] Sichuan Univ, Inst Hematol, West China Hosp, Chengdu, Peoples R China

[5] Peking Union Med Coll Hosp, Beijing, Peoples R China

[6] Jilin Univ, Hosp Bethune 1, Changchun, Peoples R China

[7] Guangzhou First Peoples Hosp, Guangzhou, Peoples R China

[8] Fudan Univ, Huashan Hosp, Shanghai, Peoples R China

[9] Nanchang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[10] Shaanxi Prov Peoples Hosp, Xian, Peoples R China

[11] Shanxi Med Univ, Hosp 2, Taiyuan, Peoples R China

[12] Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China

[13] Southeast Univ, Zhongda Hosp, Nanjing, Peoples R China

[14] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China

[15] Nantong Univ, Affiliated Hosp, Nantong, Peoples R China

[16] Henan Canc Hosp, Zhengzhou, Peoples R China

[17] Suzhou Univ, Affiliated Hosp 1, Suzhou, Peoples R China

[18] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China

来源：

ANNALS OF HEMATOLOGY | 2022年 / 101卷 / 12期

关键词：

Aplastic anemia; Hetrombopag; Iron chelation; ELTROMBOPAG; IMMUNOSUPPRESSION; DEFERASIROX; THERAPY; HEMATOPOIESIS;

D O I：

10.1007/s00277-022-04968-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hetrombopag is the only CFDA-approved thrombopoietin (TPO) receptor agonist for severe aplastic anemia (SAA) in China. Its chemical structure has an iron chelation domain. To explore the iron chelation effect of hetrombopag, we performed a post hoc analysis of the phase II clinical trial (NCT03557099). Thirty-five immunosuppressive therapy (IST)-refractory SAA patients were enrolled in the study, and the longitudinal changes of serum ferritin (SF) were assessed. At 18 weeks post-hetrombopag initiation, 51.4% of patients showed decreased SF levels by a median of 49.0 (18.1-95.5) % from baseline (median Delta SF decrease value, 917.2 ng/ml, range from 104.0 to 7030.0 ng/ml). A decrease in SF was found in 75.0% of hematologic responders and 31.6% of non-responders. Among the 24 patients with iron overload, 12 had decreased SF levels by up to 51% of the baseline. Patients with normal SF levels also showed decreased SF levels, and iron deficiency occurred in two patients. In conclusion, hetrombopag showed a powerful and rapid iron chelation effect.

引用

页码：2611 / 2616

页数：6

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