SYNTHESIS OF IMIDAZOLE C1- AND C3-RIBONUCLEOSIDE PHOSPHORAMIDITES FOR PROBING CATALYTIC MECHANISM IN RIBOZYME

被引：7

作者：

Harusawa, Shinya ^{[1
]}

Fujii, Kensuke ^{[1
]}

Nishiura, Masayoshi ^{[1
]}

Araki, Lisa ^{[1
]}

Usami, Yoshihide ^{[1
]}

Zhao, Zheng-yun ^{[2
]}

Lilley, David M. J. ^{[3
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan

[2] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[3] Univ Dundee, CR UK Nucle Acid Struct Res Grp, Dundee DD1 5EH, Scotland

来源：

HETEROCYCLES | 2011年 / 83卷 / 09期

关键词：

Imidazole; Phosphoramidite; Ribozyme; RNA; Mechanism; RIBONUCLEOSIDE PHOSPHORAMIDITE; ACTIVE-SITE; RNA;

D O I：

10.3987/COM-11-12263

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of C4-linked imidazole N-pivaloyloxymethyl (P0M)-2'-O-cyanoethylated (CE) C-1- and C-3-ribonucleoside phosphoramidites 1a and 1b is described. These phosphoramidite products were incorporated into RNA sequence through solid phase phosphoramidite approach, providing RNA with imidazole linked through different length to sugar residue, to study the mechanism of a ribozyme.

引用

页码：2041 / 2055

页数：15

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