A protic ionic liquid attenuates the deleterious actions of urea on α-chymotrypsin

被引：86
|
作者：
Attri, Pankaj [1 ]
Venkatesu, Pannuru [1 ]
Kumar, Anil [2 ]
Byrne, Nolene [3 ]
机构：
[1] Univ Delhi, Dept Chem, Delhi 110007, India
[2] Natl Chem Lab, Div Phys Chem, Pune 411008, Maharashtra, India
[3] Deakin Univ, Inst Technol Res & Innovat, Geelong, Vic 3217, Australia
来源：
PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2011年 / 13卷 / 38期
关键词：
TRIMETHYLAMINE N-OXIDE; MOLECULAR-INTERACTIONS; PROTEIN DENATURATION; REFOLDING ADDITIVES; STABILIZATION; STABILITY; WATER; FLUORESCENCE; COUNTERACTS; GDNHCL;
D O I：
10.1039/c1cp22195g
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We present a biocompatible ionic liquid, triethyl ammonium acetate (TEAA), that attenuates the denaturation action of a non-ionic chaotrope, urea, on the industrially relevant proteolytic enzyme alpha-chymotrypsin.
引用
收藏
页码：17023 / 17026
页数：4
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