Radioiodination of N-[3-(4-morphilino)propyl]-N-methyl-2-hydroxy-5-iodo-3-methyl-benzylamine (ERC9) via isotopic exchange reaction

被引：1
|
作者：
Farouk, N [1 ]
El-Tawoosy, M [1 ]
Farah, K [1 ]
机构：
[1] Atom Energy Author, Hot Labs Ctr, Radioisotope Prod Div, Labeled Cpds Dept, Cairo, Egypt
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2005年 / 264卷 / 03期
关键词：
D O I：
10.1007/s10967-005-0752-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple method for labeling ERC9 with radioactive iodine has been carried out via nucleophilic substitution radioiodination. The factors affecting the radiochemical yield of the labeling of ERC9, such as pH of the medium, substrate concentration and temperature were investigated. Chromatographic analysis technique was used to determine the radiochemical yield and purity. Kinetics and thermodynamic parameters indicated a second order reaction. Activation energy for the isotopic exchange reaction between ERC9 and I-125(-) was calculated to be 24.4 kJ/mol.
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收藏
页码：555 / 559
页数：5
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