Synthesis of a novel series of 4,4-disubstituted 2,3,4,7-tetrahydroazepines

被引：9

作者：

Barberis, M ^{[1
]}

García-Losada, P ^{[1
]}

Pleite, S ^{[1
]}

Rodríguez, JR ^{[1
]}

Soriano, JF ^{[1
]}

Mendiola, J ^{[1
]}

机构：

[1] Lilly SA, Madrid 28108, Spain

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 29期

关键词：

azepine; metathesis; pyrrolidinone; Wittig;

D O I：

10.1016/j.tetlet.2005.05.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general, simple and straightforward strategy for the synthesis of a novel series of 4,4-disubstituted 2,3,4,7-tetrahydroazepines is described. This route involves a one-pot Wittig olefination/N-allylation process on a five-membered hemi-aminal followed by a final ring closing metathesis reaction. (c) 2005 Published by Elsevier Ltd.

引用

页码：4847 / 4850

页数：4

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