STEREOSELECTIVE REDUCTION OF THE ACTIVE SUBSTANCE OF THE MEDICINAL PREPARATION DIMEBON TO THE CORRESPONDING cis- AND trans-1,2,3,4,4a,9b-HEXAHYDRO DERIVATIVES

被引：3

作者：

Alekseyev, R. S. ^{[1
]}

Ivanov, A. S. ^{[1
]}

Kurkin, A. V. ^{[1
]}

Yurovskaya, M. A. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Moscow 199992, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 46卷 / 10期

关键词：

Dimebon; 1,2,3,4-tetrahydro-gamma-carbolines; 1,2,3,4,4a,9b-hexahydro-gamma-carbolines; stereoselective reduction; STEREOSPECIFIC REDUCTION; INDOLES;

D O I：

10.1007/s10593-011-0658-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Convenient preparative methods have been developed for the reduction of the active substance of the medicinal preparation Dimebon (2,8-dimethyl-5-[2-(6-methylpyrid-3-yl)ethyl]-1,2,3,4-tetrahydro-gamma-carboline) to the corresponding racemic cis- and trans-1,2,3,4,4a,9b-hexahydro derivatives, distinguished by a high degree of stereoselectivity. The structures of the obtained diastereomeric hexahydro-gamma-carbolines were confirmed by various physicochemical methods, including X-ray structural analysis.

引用

页码：1239 / 1249

页数：11

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