Enantioselective organocatalytic Michael additions to acrylic acid derivatives: generation of all-carbon quaternary stereocentres

被引：60
|
作者：
Rigby, Caroline L. [1 ]
Dixon, Darren J. [1 ]
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
来源：
CHEMICAL COMMUNICATIONS | 2008年 / 32期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1039/b805233f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Acrylic esters, thioesters and N-acryloyl pyrrole have been identified as effective electrophiles in the enantioselective Michael addition reaction with beta-keto ester pro-nucleophiles catalysed by a cinchona alkaloid derived bifunctional organocatalyst; enantiomeric excesses of up to 98% and yields of up to 96% can be obtained for a range of Michael acceptors and pro-nucleophiles.
引用
收藏
页码：3798 / 3800
页数：3
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