Recombinant lactic acid bacteria as mucosal biotherapeutic agents

被引：76

作者：

Daniel, Catherine ^{[1
]}

Roussel, Yvonne ^{[2
]}

Kleerebezem, Michiel ^{[3
,4
]}

Pot, Bruno ^{[1
]}

机构：

[1] Univ Lille Nord France, CNRS, Inst Pasteur Lille,UMR 8204,U1019, Ctr Infect & Immun Lille,Inst Natl St & Rech Med, F-59019 Lille, France

[2] Nancy Univ, Unite Rech Anim & Fonctionnalites Prod Anim, Equipe Proteolyse Biofonctionnalite Prot & Peptid, Fac Sci & Tech,UHP, F-54506 Vandoeuvre Les Nancy, France

[3] NIZO Food Res, Dept Hlth, NL-6710 BA Ede, Netherlands

[4] Wageningen Univ, Microbiol Lab, NL-6703 HB Wageningen, Netherlands

来源：

TRENDS IN BIOTECHNOLOGY | 2011年 / 29卷 / 10期

关键词：

LACTOBACILLUS-PLANTARUM GENES; MODIFIED LACTOCOCCUS-LACTIS; IN-VIVO; IMMUNOMODULATORY PROPERTIES; LISTERIA-MONOCYTOGENES; PROTECTIVE ANTIGEN; IMMUNE-RESPONSES; EPITHELIAL-CELLS; VACCINE DELIVERY; LETHAL CHALLENGE;

D O I：

10.1016/j.tibtech.2011.05.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The safety status of lactic acid bacteria (LAB) and their capacity to survive the passage through the gastrointestinal tract (GI tract) have rendered them excellent candidates for the production of therapeutic proteins and their delivery in situ to the GI tract. During the past two decades, major health benefits of mucosally administered recombinant LAB have been successfully demonstrated, predominantly using animal models. However, the field has recently moved into the era of human clinical trials. In this review, we provide a timely update on the recent important advances made in this field, and outline the potential of recombinant LAB as therapeutic tools for their safe and efficient use in human health.

引用

页码：499 / 508

页数：10

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