Influence of aqueous dimethyl sulfoxide on pyridoxine protonation and tautomerization

被引：5
|
作者：
Gamov, G. A. [1 ]
Zavalishin, M. N. [1 ]
Khokhlova, A. Yu. [1 ]
Sharnin, V. A. [1 ,2 ]
机构：
[1] Ivanovo State Univ Chem & Technol, Res Inst Thermodynam & Kinet Chem Proc, Ivanovo, Russia
[2] Russian Acad Sci, GA Krestov Inst Solut Chem, Ivanovo, Russia
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 221卷
基金：
俄罗斯基础研究基金会;
关键词：
Pyridoxine; Protonation constant; Tautomeric constant; Gibbs energy change of transfer; Binary solvent; Transmembrane transport; DRUG DISCOVERY; HYDROGEN-BONDS; WATER; EQUILIBRIA; NMR; DIMETHYLSULFOXIDE; PERMEABILITY; COPPER(II); STABILITY; COMPLEXES;
D O I：
10.1016/j.molliq.2016.06.031
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The constants of pyridoxine (vitamin B-6) protolytic and tautomeric equilibria were determined by means of potentiometry and spectrophotometry respectively in wide range of binary solvent (aqueous dimethyl sulfoxide) compositions. The free Gibbs energies of pyridoxine molecular and zwitterionic species transfer from water to aqueous DMSO were obtained using method of partition between immiscible phases. These results were employed for discussing the transmembrane transport capability of B-6 vitamin. The influence of mixed solvent composition on pyridoxine protonation was analyzed taking into account the reagents solvation data. (C) 2016 Elsevier B.V. All rights reserved.
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页码：457 / 462
页数：6
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