RETRACTED: Impact of ANN in Revealing of Viral Peptides (Retracted Article)

被引:1
|
作者
Rajkumar, M. [1 ]
Bhukya, Shankar Nayak [2 ]
Ahalya, N. [3 ]
Elumalai, G. [4 ]
Sivanandam, K. [5 ]
Almutairi, Khalid M. A. [6 ]
Alonazi, Wadi B. [7 ]
Soma, S. R. [8 ]
Urugo, Markos Makiso [9 ]
机构
[1] Rajalakshmi Engn Coll, Dept Comp Sci & Engn, Chennai, Tamil Nadu, India
[2] CMR Tech Campus, Dept Comp Sci & Engn Data Sci, Hyderabad 501401, Telangana, India
[3] MS Ramaiah Inst Technol, Dept Biotechnol, Bengaluru 560054, Karnataka, India
[4] Panimalar Engn Coll, Dept Elect & Commun Engn, Chennai 600123, Tamil Nadu, India
[5] M Kumarasamy Coll Engn, Dept Elect & Commun Engn, Karur 639113, Tamil Nadu, India
[6] King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, POB 10219, Riyadh 11433, Saudi Arabia
[7] King Saud Univ, Coll Business Adm, Hlth Adm Dept, POB 71115, Riyadh 11587, Saudi Arabia
[8] Univ Tennessee Hlth Sci Ctr, Dept Biol, Memphis, TN USA
[9] Wachamo Univ, Coll Agr Sci, Dept Food Sci & Postharvest Technol, Hosaena, Ethiopia
关键词
ANTIMICROBIAL ACTIVITY; IDENTIFICATION; NANOPARTICLES;
D O I
10.1155/2022/7760734
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
All organisms contain antimicrobial peptides (AMPs), which are a critical component of the innate immune system. These chemicals have the ability to suppress the growth of a variety of fungi, bacteria, and viruses. Because AMPs interact with structural components of the microbial cell membrane and have a wide range of cellular targets, bacteria are unlikely to be able to develop resistance to them in the short term. The underlying structure of AMPs is critical in determining the selectivity with which they target their respective targets. As far as we know, peptides have not been tested in a lab to see if they can fight bacteria, fungus, and viruses in real life. In this paper, we develop an artificial neural network (ANN) using a back propagation neural network (BPNN) that enables optimal classification of tendency of a peptide sequence that involves the activities of antifungal, antibacterial, or antiviral. The BPNN is trained on the datasets collected across different repositories and then the overfitting is avoided using particle swarm optimization (PSO) algorithm. Hence, at the time of testing, the BPNN clearly finds the predicted samples belonging to the same classes and this avoids the problem of finding the false positives. The simulation is conducted to test the efficacy of the model against various metrics that includes accuracy, precision, recall, and f1-measure. The effectiveness of the BPNN-PSO model in classifying instances at a faster rate than other techniques is demonstrated by its performance. The principle is straightforward, it is not difficult to programme, it converges more quickly, and it generally offers a superior solution.
引用
收藏
页数:8
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