Palladium-Catalyzed Hydroaminocarbonylation of Alkynes with Tertiary Amines via C-N Bond Cleavage

被引：66
|
作者：
Gao, Bao [1 ]
Huang, Hanmin [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 22期
基金：
中国国家自然科学基金;
关键词：
CARBON-NITROGEN BOND; ALPHA; BETA-UNSATURATED AMIDES; DEALKYLATIVE CARBONYLATION; REGIOSELECTIVE SYNTHESIS; MONO(AMINE) COMPLEXES; ANILINE DERIVATIVES; SAMARIUM DIIODIDE; ARYL IODIDES; ACTIVATION; AMINALS;
D O I：
10.1021/acs.orglett.7b03331
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient strategy for the cleavage of the CN bond of tertiary amines was developed with DTBP as an oxidant, in which the cleaved H atom and amine moiety were successfully transferred to the desired products. This strategy has enabled an efficient palladium-catalyzed hydroaminocarbonylation of alkynes with tertiary amines. Notably, the catalyst loading could be lowered from 5 to 0.1 mol %, which represents the lowest catalyst loading among the reported work on carbonylation via CN bond activation.
引用
收藏
页码：6260 / 6263
页数：4
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