Molecular Characteristics of Response to Olutasidenib (FT-2102) in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia

被引:2
|
作者
De Botton, Stephane [1 ]
Yee, Karen [2 ]
Recher, Christian [3 ]
Wei, Andrew H. [4 ]
Montesinos, Pau [5 ]
Taussig, David [6 ]
Pigneux, Arnaud [7 ]
Braun, Thorsten [8 ]
Curti, Antonio [9 ]
Esteve, Jordi [10 ]
Grove, Carolyn [11 ]
Jonas, Brian A. [12 ]
Khwaja, Asim [13 ,14 ]
Legrand, Olivier [15 ]
Peterlin, Pierre [16 ]
Sangerman, Montserrat Arnan [17 ]
Blum, William G. [18 ]
Cilloni, Daniela [19 ]
Hiwase, Devendra [20 ]
Jurcic, Joseph G. [21 ]
Krauter, Jurgen [22 ]
Thomas, Xavier [23 ]
Watts, Justin [24 ]
Yang, Jay [25 ]
Xin, Zihao [26 ]
Sedkov, Alex [26 ]
Guichard, Sylvie [26 ]
Sweeney, Jennifer [26 ]
Marzac, Christophe [27 ]
Cortes, Jorge E. [28 ]
Fenaux, Pierre [29 ]
机构
[1] Inst Gustave Roussy, Dept Haematol, Villejuif, France
[2] Princess Margaret Canc Ctr, Toronto, ON, Canada
[3] Inst Univ Canc Toulouse Oncopole, Paris, France
[4] Alfred Hosp, Dept Haematol, Melbourne, Australia
[5] Hosp Univ Politecn La Fe Valencia, Dept Hematol, Valencia, Spain
[6] Royal Marsden NHS Fdn Trust, Sutton, Surrey, England
[7] Univ Bordeaux, Dept Hematol, Ctr HospUniv CHU Bordeaux, Bordeaux, France
[8] Paris XIII Univ, Hop Avicenne, AP HP, Bobigny, France
[9] IRCCS Azienda Osped Univ Bologna, Ist Ematol Seragnoli, Bologna, Italy
[10] Hosp Clin Barcelona, Dept Hematol, Barcelona, Spain
[11] PathWest Sir Charles Gairdner Hosp, Dept Haematol, Dept Hlth, Nedlands, WA, Australia
[12] Univ Calif Davis, Div Hematol & Oncol, Dept Internal Med, Davis, CA USA
[13] Univ Coll London Hosp, London, England
[14] Univ Coll Canc Inst, London, England
[15] St Antoine Univ Hosp, Dept Hematol, Paris, France
[16] CHU Nantes, Serv Hematol Clin, Nantes, France
[17] IDIBELL, Inst Catala Oncol, Hosp Duran & Reynals, Clin Hematol Dept, Barcelona, Spain
[18] Emory Univ, Winship Canc Inst, Atlanta, GA USA
[19] Univ Turin, Dept Clin & Biol Sci, Turin, Italy
[20] Royal Adelaide Hosp, Dept Haematol, Adelaide, SA, Australia
[21] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Med Ctr, New York, NY USA
[22] Braunschweig Municipal Hosp, Dept Internal Med 3, Braunschweig, Germany
[23] Lyon Sud Univ Hosp, Hosp Civils Lyon, Dept Hematol, Pierre Benite, France
[24] Univ Miami, Dept Med, Leukemia Program, Sylvester Comprehens Canc Ctr, Miami, FL USA
[25] Karmanos Canc Inst, Dept Oncol, Detroit, MI USA
[26] Forma Therapeut Inc, Watertown, MA USA
[27] Univ Paris Saclay, Dept Biol pathol, Gustave Roussy, Villejuif, France
[28] Georgia Canc Ctr, Augusta, GA USA
[29] St Louis Hosp, Dept Haematol, Paris, France
关键词
D O I
10.1182/blood-2021-144912
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2351
引用
收藏
页数:9
相关论文
共 50 条
  • [41] EXPOSURE-RESPONSE ANALYSIS OF IVOSIDENIB IN PATIENTS WITH IDH1-MUTANT RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA.
    Le, K.
    Kleijn, H. J.
    Dai, D.
    Fan, B.
    Liu, H.
    Attar, E. C.
    Hickman, D.
    Agresta, S. V.
    Yang, H.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 105 : S85 - S85
  • [42] MOLECULAR PREDICTORS OF RESPONSE AND OUTCOME IN PATIENTS WITH REFRACTORY/RELAPSED ACUTE MYELOID LEUKEMIA RECEIVING VENETOCLAX PLUS NON-INTENSIVE CHEMOTHERAPY
    Krueger, K.
    Beutel, G.
    Gabdoulline, R.
    Koenecke, C.
    Stadler, M.
    Gohring, G.
    Behrens, Y.
    Trummer, A.
    Krauter, J.
    Kaun, S.
    Voss, A.
    Goetze, K.
    Braitsch, K.
    Wichmann, M.
    Thol, F.
    Heuser, M.
    Shahswar, R.
    ANNALS OF HEMATOLOGY, 2023, 102 (SUPPL 1) : S41 - S41
  • [43] Phase 1 trial of linifanib (ABT-869) in patients with refractory or relapsed acute myeloid leukemia
    Wang, Eunice S.
    Yee, Karen
    Koh, Liang Piu
    Hogge, Donna
    Enschede, Sari
    Carlson, Dawn M.
    Dudley, Atthew
    Glaser, Keith
    McKeegan, Evelyn
    Albert, Daniel H.
    Li, Xiaohui
    Pradhan, Rajendra
    Stock, Wendy
    LEUKEMIA & LYMPHOMA, 2012, 53 (08) : 1543 - 1551
  • [44] Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia
    DeAngelo, Daniel J.
    Jonas, Brian A.
    Liesveld, Jane L.
    Bixby, Dale L.
    Advani, Anjali S.
    Marlton, Paula
    Magnani, John L.
    Thackray, Helen M.
    Feldman, Eric J.
    O'Dwyer, Michael E.
    Becker, Pamela S.
    BLOOD, 2022, 139 (08) : 1135 - 1146
  • [45] A phase 1b study of venetoclax and alvocidib in patients with relapsed/refractory acute myeloid leukemia
    Jonas, Brian A.
    Hou, Jing-Zhou
    Roboz, Gail J.
    Alvares, Caroline L.
    Jeyakumar, Deepa
    Edwards, John R.
    Erba, Harry P.
    Kelly, Richard J.
    Roellig, Christoph
    Fiedler, Walter
    Brackman, Deanna
    Siddani, Satya R.
    Chyla, Brenda
    Hilger-Rolfe, Jacqueline
    Watts, Justin M.
    HEMATOLOGICAL ONCOLOGY, 2023, 41 (04) : 743 - 752
  • [46] Safety and pharmacokinetics of quizartinib in Japanese patients with relapsed or refractory acute myeloid leukemia in a phase 1 study
    Kensuke Usuki
    Hiroshi Handa
    Ilseung Choi
    Takahiro Yamauchi
    Hiroatsu Iida
    Tomoko Hata
    Shoichi Ohwada
    Noriko Okudaira
    Kota Nakamura
    Sakura Sakajiri
    International Journal of Hematology, 2019, 110 : 654 - 664
  • [47] Safety and pharmacokinetics of quizartinib in Japanese patients with relapsed or refractory acute myeloid leukemia in a phase 1 study
    Usuki, Kensuke
    Handa, Hiroshi
    Choi, Ilseung
    Yamauchi, Takahiro
    Iida, Hiroatsu
    Hata, Tomoko
    Ohwada, Shoichi
    Okudaira, Noriko
    Nakamura, Kota
    Sakajiri, Sakura
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2019, 110 (06) : 654 - 664
  • [48] Identification of molecular predictors of response to ZARNESTRA™ (tipifarnib, R115777) in relapsed and refractory acute myeloid leukemia.
    Raponi, M
    Lowenberg, B
    Lancet, JE
    Harousseau, JL
    Stone, R
    Rackoff, W
    Thibault, A
    Zhang, Y
    Atkins, D
    Wang, YX
    BLOOD, 2004, 104 (11) : 246A - 246A
  • [49] RUNX1 mutations correlate with response to venetoclax combination therapies in relapsed/refractory acute myeloid leukemia
    Chow, Signy
    Tang, Kenny
    Al-Abri, Mahmood
    Hall, Victoria
    Tremblay-Lemay, Rosemarie
    Rashedi, Iran
    Tsui, Hubert
    Chan, Steven M.
    LEUKEMIA RESEARCH, 2021, 111
  • [50] A Phase 1 Trial of Valemetostat in Patients With Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Acute Lymphocytic Leukemia (ALL)
    Erba, Harry P.
    Oluwole, Olalekan O.
    Bixby, Dale
    Rampal, Raajit K.
    Fathi, Amir T.
    Paliwal, Prashni
    Jin, Jin
    Inoue, Ai
    Daver, Naval
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S311 - S312