Enantioselective conjugate addition of diethylzinc to acyclic enones using a copper phosphino-phenol complex as catalyst

被引：31
|
作者：
Ito, K [1 ]
Eno, S
Saito, B
Katsuki, T
机构：
[1] Fukuoka Univ Educ, Dept Chem, Fukuoka 8114192, Japan
[2] Kyushu Univ, Grad Sch, Dept Chem, Fac Sci,Higashi Ku, Fukuoka 8128581, Japan
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 23期
基金：
日本科学技术振兴机构;
关键词：
copper; asymmetric catalysis; phosphino-phenol; conjugate addition;
D O I：
10.1016/j.tetlet.2005.04.036
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Newly designed phosphino-phenol 1c was found to be an efficient chiral auxiliary for copper-mediated asymmetric conjugate addition of diethylzine to acyclic enones. High enantio selectivity up to > 99% ee was achieved in the reaction of acyclic alpha,beta-enones. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3981 / 3985
页数：5
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