Functional Genomics for Cancer Drug Target Discovery

被引：49

作者：

Haley, Benjamin ^{[1
]}

Roudnicky, Filip ^{[2
]}

机构：

[1] Genentech Inc, Mol Biol Dept, 1 DNA Way, San Francisco, CA 94080 USA

[2] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Pharmaceut Res & Early Dev, CH-4070 Basel, Switzerland

来源：

CANCER CELL | 2020年 / 38卷 / 01期

关键词：

LARGE-SCALE; SYNTHETIC LETHALITY; CRISPR-CAS9; SCREENS; GENE ESSENTIALITY; RNAI; SHRNA; GUIDE; IDENTIFICATION; CRISPR/CAS9; MUTAGENESIS;

D O I：

10.1016/j.ccell.2020.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Functional genomics describes a field of biology that uses a range of approaches for assessing gene function with high-throughput molecular, genetic, and cellular technologies. The near limitless potential for applying these concepts to study the activities of all genetic loci has completely upended how today's cancer biologists tackle drug target discovery. We provide an overview of contemporary functional genomics platforms, highlighting areas of distinction and complementarity across technologies, so as to aid in the development or interpretation of cancer-focused screening efforts.

引用

页码：31 / 43

页数：13

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