Therapeutic Plasma Concentrations of Antidepressants and Antipsychotics: Lessons from PET Imaging

被引：40
|
作者：
Gruender, G. [1 ,2 ]
Hiemke, C. [3 ]
Paulzen, M. [1 ,2 ]
Veselinovic, T. [1 ,2 ]
Vernaleken, I. [1 ,2 ]
机构：
[1] Rhein Westfal TH Aachen, Fac Med, Dept Psychiat Psychotherapy & Psychosomat, D-52074 Aachen, Germany
[2] JARA Translat Brain Med, Aachen, Germany
[3] Univ Med Ctr Mainz, Dept Psychiat & Psychotherapy, Mainz, Germany
来源：
PHARMACOPSYCHIATRY | 2011年 / 44卷 / 06期
关键词：
therapeutic drug monitoring (TDM); positron emission tomography (PET); plasma concentration; antidepressant; antipsychotic; POSITRON-EMISSION-TOMOGRAPHY; DOPAMINE-D-2 RECEPTOR OCCUPANCY; SEROTONIN TRANSPORTER OCCUPANCY; ACTING INJECTABLE RISPERIDONE; PLACEBO-CONTROLLED TRIAL; SCHIZOPHRENIC-PATIENTS; TIME-COURSE; SCHIZOAFFECTIVE DISORDER; CLINICAL-RESPONSE; REUPTAKE INHIBITORS;
D O I：
10.1055/s-0031-1286282
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Therapeutic Drug Monitoring (TDM) of psychotropic drugs is strongly depending on the validity of recommended therapeutic plasma concentration reference ranges. Rational pharmacotherapy is based on the assumption that plasma concentrations are directly related to target occupancy by the respective drug. Here we show that positron emission tomography (PET) of molecular drug targets in the brain (neuroreceptors and transporters) allows for establishment of these relationships, thereby providing guidance for TDM services. Associations between brain target occupancy, plasma concentrations, and clinical effects and adverse reactions will be discussed for the most commonly used antidepressant and antipsychotic drugs.
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页码：236 / 248
页数：13
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