Effects of iodoacetic acid drinking water disinfection byproduct on the gut microbiota and its metabolism in rats

被引:9
|
作者
Sha, Yujie [1 ]
Wu, Huan [1 ]
Guo, Yue [2 ]
Liu, Xi [2 ]
Mo, Yan [1 ]
Yang, Qiyuan [1 ]
Wei, Shumao [1 ]
Long, Kunling [1 ]
Lu, Du [1 ]
Xia, Ying [1 ]
Zheng, Weiwei [3 ]
Su, Zhiheng [2 ]
Wei, Xiao [1 ,4 ,5 ,6 ]
机构
[1] Guangxi Med Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Nanning 530021, Peoples R China
[2] Guangxi Med Univ, Guangxi Key Lab Bioact Mol Res & Evaluat, Pharmaceut Coll, Nanning 530021, Peoples R China
[3] Fudan Univ, Key Lab Publ Hlth Safety, Minist Educ, Dept Environm Hlth,Sch Publ Hlth, Shanghai 200032, Peoples R China
[4] Guangxi Med Univ, Key Lab Longev & Agingrelated Dis, Chinese Minist Educ, Nanning 530021, Peoples R China
[5] Guangxi Med Univ, Guangxi Coll & Univ, Key Lab Prevent & Control Highly Prevalent Dis, Sch Publ Hlth, Nanning 530021, Peoples R China
[6] Guangxi Med Univ, Guangxi Key Lab Environm & Hlth Res, Nanning 530021, Peoples R China
来源
JOURNAL OF ENVIRONMENTAL SCIENCES | 2022年 / 117卷
基金
中国国家自然科学基金;
关键词
Iodoacetic acid; Drinking water; Disinfection byproducts; Gut microbiota; Metabolomics; CHRONIC EXPOSURE; INCREASES; DISORDER; IDENTIFICATION; ACCUMULATION; CYTOTOXICITY; POLLUTANTS; BIOMARKERS; OBESITY; AMINES;
D O I
10.1016/j.jes.2022.02.048
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Iodoacetic acid (IAA) is an unregulated disinfection byproduct in drinking water and has been shown to exert cytotoxicity, genotoxicity, tumorigenicity, and reproductive and developmental toxicity. However, the effects of IAA on gut microbiota and its metabolism are still unknown, especially the association between gut microbiota and the metabolism and toxicity of IAA. In this study, female and male Sprague-Dawley rats were exposed to IAA at 0 and 16 mg/kg bw/day daily for 8 weeks by oral gavage. Results of 16S rRNA gene sequencing showed that IAA could alter the diversity, relative abundance and function of gut microbiota in female and male rats. IAA also increased the abundance of genes related to steroid hormone biosynthesis in the gut microbiota of male rats. Moreover, metabolomics profiling revealed that IAA could significantly disturb 6 and 13 metabolites in the feces of female and male rats, respectively. In female rats, the level of androstanediol increased in the IAA treatment group. These results were consistent with our previous findings, where IAA was identified as an androgen disruptor. Additionally, the perturbed gut microbiota and altered metabolites were correlated with each other. The results of this study indicated that IAA could disturb gut microbiota and its metabolism. These changes in gut microbiota and its metabolism were associated with the reproductive and developmental toxicity of IAA. (C) 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
引用
收藏
页码:91 / 104
页数:14
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