Prognostic significance of CYFRA 21-1 in non-small cell lung cancer

被引：0
|
作者：
Hirashima, T
Takada, M
Komiya, T
Nitta, T
Masashi, K
Masuda, N
Matui, K
Kikui, M
Yasumitsu, T
Kawase, I
机构：
[1] Osaka Prefectural Habikino Hosp, Dept Internal Med, Habikino, Osaka 5838588, Japan
[2] Osaka Prefectural Habikino Hosp, Dept Surg, Habikino, Osaka 5838588, Japan
[3] Osaka Prefectural Habikino Hosp, Dept Pathol, Habikino, Osaka 5838588, Japan
[4] Izumisano Municipal Hosp, Div Resp, Izumisano, Osaka 5988577, Japan
来源：
ANTICANCER RESEARCH | 1998年 / 18卷 / 6B期
关键词：
non-small cell lung cancer; CYFRA; 21-1; prognostic factor;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Between July 1991 and February 1993, CYFRA 21-1 levels of 149 newly diagnosed patients with histologically proven non-small cell lung cancer (NSCLC) at Osaka Prefectural Habikino Hospital were measured with an enzyme immunoassay method developed by Boeringer Mannheim (Enzymum-Test CYFRA 21-1). NSCLC patients with CYFRA 21-1 serum levels over 3.5 ng/ml had a significantly poorer prognosis than did patients with normal CYFRA 21-1 levels (P<0.001). Univariate analysis revealed that CYFRA 21-1 levels above 3.5 ng/ml, poor PS, advanced stage and serum LDH over 450U/l strongly correlated with survival period. In multivariate analysis, however, only CYFRA 21-1 was found to be an independent prognostic factor compatible with Stage and PS (P=0.0040 for CYFRA 21-1, P<0.001 for PS, P=0.0052 for Stage).
引用
收藏
页码：4713 / 4716
页数：4
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