Association of tumour mutational burden (TMB) with outcomes in stage IIIA(N2) non-small cell lung cancer (NSCLC) patients treated with neoadjuvant chemotherapy and durvalumab: prospective analysis of the multicenter single-arm phase II trial SAKK16/14

被引:0
|
作者
Alborelli, I [1 ]
Jermann, P. M. [2 ]
Leonards, K. [2 ]
Manzo, M. [2 ]
Keller, E. [2 ]
Zippelius, A. [1 ,3 ]
Eboulet, E., I [4 ]
Betticher, D. [5 ]
Frueh, M. [6 ]
Britschgi, C. [7 ]
Peters, S. [8 ]
Mark, M. [9 ]
Ochsenbein, A. F. [10 ]
Janthur, W. -D [11 ]
Waibel, C. [12 ]
Mach, N. [13 ]
Froesch, P. [14 ]
Pless, M. [15 ]
Prince, Savic S. [2 ]
Rothschild, S. [1 ]
机构
[1] Univ Spital Basel, Med Onkol, Basel, Switzerland
[2] Univ Spital Basel, Inst Pathol, Basel, Switzerland
[3] Univ Spital Basel, Dept Biomed Lab Tumorimmunol, Basel, Switzerland
[4] Schweizer Arbeitsgemeinschaft Klin Krebsforsch SA, Bern, Switzerland
[5] HFR Fribourg Hop Fribourgeois, Med Onkol, Fribourg, Switzerland
[6] Kantonsspital St Gallen, Onkol Hamatol, St Gallen, Switzerland
[7] Univ Spital Zurich, Med Onkol & Hamatol, Zurich, Switzerland
[8] Ctr Hosp Univ Vaudois CHUV, Med Onkol, Lausanne, Switzerland
[9] Kantonsspital Graubunden, Onkol Hamatol, Chur, Switzerland
[10] Inselspital Bern, Med Onkol, Bern, Switzerland
[11] Kantonsspital Aarau, Onkol Hamatol & Transfus Med, Aarau, Switzerland
[12] Kantonsspital Baden, Onkol Hamatol, Baden, Switzerland
[13] Hop Univ Geneve, Med Onkol, Geneva, Switzerland
[14] Ist Oncol Svizzera Italiana IOSI, Bellinzona, Switzerland
[15] Kantonsspital Winterthur, Med Onkol, Winterthur, Switzerland
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
ep658
引用
收藏
页码:174 / 175
页数:2
相关论文
共 50 条
  • [41] Perioperative serplulimab and chemotherapy in patients with resectable squamous non-small cell lung cancer: An open-label, single-arm, phase II trial
    Chen, H.
    Hu, H.
    Fu, F.
    ANNALS OF ONCOLOGY, 2024, 35 : S787 - S787
  • [42] Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: Results of CALGB Protocol 39803
    Jaklitsch, Michael T.
    Gu, Lin
    Demmy, Todd
    Harpole, David H.
    D'Amico, Thomas A.
    McKenna, Robert J.
    Krasna, Mark J.
    Kohman, Leslie J.
    Swanson, Scott J.
    DeCamp, Malcolm M.
    Wang, Xiaofei
    Barry, Susan
    Sugarbaker, David J.
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2013, 146 (01): : 9 - 16
  • [43] Ramucirumab Plus Docetaxel for Patients with Non-small cell Lung Cancer with Brain Metastases: A Multicenter, Open-Label Single-Arm Phase II Trial
    Tanimura, Keiko
    Uchino, Junji
    Kimura, Hideharu
    Hiranuma, Osamu
    Chihara, Yusuke
    Tanzawa, Shigeru
    Takumi, Chieko
    Kita, Toshiyuki
    Inoue, Koji
    Minato, Koichi
    Takemoto, Shinnosuke
    Nakao, Akira
    Yoshimura, Kenichi
    Takayama, Koichi
    ONCOLOGIST, 2023, 28 (06): : 551 - +
  • [44] Neoadjuvant atezolizumab and chemotherapy in patients with resectable non-small-cell lung cancer: an open-label, multicentre, single-arm, phase 2 trial
    Shu, Catherine A.
    Gainor, Justin F.
    Awad, Mark M.
    Chiuzan, Codruta
    Grigg, Claud M.
    Pabani, Aliyah
    Garofano, Robert F.
    Stoopler, Mark B.
    Cheng, Simon K.
    White, Abby
    Lanuti, Michael
    D'Ovidio, Frank
    Bacchetta, Matthew
    Sonett, Joshua R.
    Saqi, Anjali
    Rizvi, Naiyer A.
    LANCET ONCOLOGY, 2020, 21 (06): : 786 - 795
  • [45] Nivolumab plus ipilimumab with chemotherapy for non-small cell lung cancer with untreated brain metastases: A multicenter single-arm phase 2 trial (NIke, LOGiK 2004)
    Tsuchiya-Kawano, Yuko
    Shiraishi, Yoshimasa
    Tanaka, Kentaro
    Tachihara, Motoko
    Saito, Ryota
    Okamoto, Tatsuro
    Sugasaki, Nanae
    Nakatomi, Keita
    Kiyomi, Fumiaki
    Okamoto, Isamu
    EUROPEAN JOURNAL OF CANCER, 2024, 212
  • [46] Efficiency and safety of neoadjuvant PD-1 inhibitor (sintilimab) combined with chemotherapy in potentially resectable stage IIIA/IIIB non-small cell lung cancer: Neo-Pre-IC, a single-arm phase 2 trial
    Sun, Chao
    Wang, Xu
    Xu, Yinghui
    Shao, Guoguang
    Chen, Xi
    Liu, Yunpeng
    Zhang, Peng
    Lin, Xingyu
    Ma, Xiaobo
    Qiu, Shi
    He, Hua
    Yang, Zhiguang
    Ma, Kewei
    ECLINICALMEDICINE, 2024, 68
  • [47] Nivolumab for advanced non-small cell lung cancer patients with mild idiopathic interstitial pneumonia: A multicenter, open-label single-arm phase II trial
    Fujimoto, Daichi
    Yomota, Makiko
    Sekine, Akimasa
    Morita, Mitsunori
    Morimoto, Takeshi
    Hosomi, Yukio
    Ogura, Takashi
    Tomioka, Hiromi
    Tomii, Keisuke
    LUNG CANCER, 2019, 134 : 274 - 278
  • [48] Interim analysis of the efficiency and safety of neoadjuvant PD-1 inhibitor (sintilimab) combined with chemotherapy (nab-paclitaxel and carboplatin) in potentially resectable stage IIIA/IIIB non-small cell lung cancer: a single-arm, phase 2 trial
    Sun, Chao
    Liu, Yunpeng
    Zhang, Peng
    Wang, Xu
    Xu, Yinghui
    Lin, Xingyu
    Ma, Xiaobo
    Guo, Ye
    Qiu, Shi
    Shao, Guoguang
    Yang, Zhiguang
    Ma, Kewei
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (02) : 819 - 831
  • [49] Interim analysis of the efficiency and safety of neoadjuvant PD-1 inhibitor (sintilimab) combined with chemotherapy (nab-paclitaxel and carboplatin) in potentially resectable stage IIIA/IIIB non-small cell lung cancer: a single-arm, phase 2 trial
    Chao Sun
    Yunpeng Liu
    Peng Zhang
    Xu Wang
    Yinghui Xu
    Xingyu Lin
    Xiaobo Ma
    Ye Guo
    Shi Qiu
    Guoguang Shao
    Zhiguang Yang
    Kewei Ma
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 819 - 831
  • [50] A phase II single-arm study of LDK378 in patients with ALK-activated (ALK plus ) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ).
    Shaw, Alice Tsang
    Mok, Tony
    Spigel, David R.
    Nishio, Makoto
    Felip, Enriqueta
    Tan, Daniel Shao-Weng
    Garcia-Campelo, M. Rosario
    Gruen, Harry J. M.
    Dakhil, Shaker R.
    Schaefer, Eric Scott
    Farrell, Nicholas John
    Blakesley, Rick E.
    Weir, Alexander
    Ristic, Mirta
    Selvaggi, Giovanni
    Scagliotti, Giorgio
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)