Prediction of Hospitalizations in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index

被引：15

作者：

Legge, Alexandra ^{[1
]}

Kirkland, Susan ^{[1
]}

Rockwood, Kenneth ^{[1
]}

Andreou, Pantelis ^{[1
]}

Bae, Sang-Cheol ^{[2
]}

Gordon, Caroline ^{[3
]}

Romero-Diaz, Juanita ^{[4
]}

Sanchez-Guerrero, Jorge ^{[4
]}

Wallace, Daniel J. ^{[5
]}

Bernatsky, Sasha ^{[6
]}

Clarke, Ann E. ^{[7
]}

Merrill, Joan T. ^{[8
]}

Ginzler, Ellen M. ^{[9
]}

Fortin, Paul R. ^{[10
]}

Gladman, Dafna D. ^{[11
,12
]}

Urowitz, Murray B. ^{[11
,12
]}

Bruce, Ian N. ^{[13
,14
]}

Isenberg, David A. ^{[15
]}

Rahman, Anisur ^{[15
]}

Alarcon, Graciela S. ^{[16
]}

Petri, Michelle ^{[17
]}

Khamashta, Munther A. ^{[18
]}

Dooley, M. A. ^{[19
]}

Ramsey-Goldman, Rosalind ^{[20
,21
]}

Manzi, Susan ^{[22
]}

Zoma, Asad A. ^{[23
]}

Aranow, Cynthia ^{[24
]}

Mackay, Meggan ^{[24
]}

Ruiz-Irastorza, Guillermo ^{[25
,26
]}

Lim, S. Sam ^{[27
]}

Inanc, Murat ^{[28
]}

van Vollenhoven, Ronald F. ^{[29
]}

Jonsen, Andreas ^{[30
]}

Nived, Ola ^{[30
]}

Ramos-Casals, Manuel ^{[31
]}

Kamen, Diane L. ^{[32
]}

Kalunian, Kenneth C. ^{[33
]}

Jacobsen, Soren ^{[34
]}

Peschken, Christine A. ^{[35
]}

Askanase, Anca ^{[36
]}

Hanly, John G. ^{[1
,37
]}

机构：

[1] Dalhousie Univ, Halifax, NS, Canada

[2] Hanyang Univ, Hosp Rheumat Dis, Seoul, South Korea

[3] Univ Birmingham, Coll Med & Dent Sci, Birmingham, W Midlands, England

[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

[5] Univ Calif Los Angeles, Cedars Sinai David Geffen Sch Med, Los Angeles, CA USA

[6] McGill Univ, Montreal, PQ, Canada

[7] Univ Calgary, Cumming Sch Med, Calgary, AB, Canada

[8] Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA

[9] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA

[10] Univ Laval, CHU Quebec, Quebec City, PQ, Canada

[11] Toronto Western Hosp, Toronto, ON, Canada

[12] Univ Toronto, Toronto, ON, Canada

[13] Univ Manchester, Manchester Univ NHS Fdn Trust, NIHR Manchester Musculoskeletal Biomed Res Ctr, Manchester, Lancs, England

[14] Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[15] UCL, London, England

[16] Univ Alabama Birmingham, Birmingham, AL USA

[17] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[18] Kings Coll London, Sch Med, St Thomas Hosp, London, England

[19] Univ N Carolina, Chapel Hill, NC 27515 USA

[20] Northwestern Univ, Chicago, IL 60611 USA

[21] Feinberg Sch Med, Chicago, IL 60611 USA

[22] Allegheny Hlth Network, Pittsburgh, PA USA

[23] Hairmyres Hosp, East Kilbride, Scotland

[24] Feinstein Inst Med Res, Manhasset, NY USA

[25] Hosp Univ Cruces, BioCruces Bizkaia Hlth Res Inst, Baracaldo, Spain

[26] Univ Basque Country, Baracaldo, Spain

[27] Emory Univ, Sch Med, Atlanta, GA USA

[28] Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey

[29] Karolinska Inst, Stockholm, Sweden

[30] Lund Univ, Lund, Sweden

[31] Hosp Clin Barcelona, Barcelona, Spain

[32] Med Univ South Carolina, Charleston, SC 29425 USA

[33] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA

[34] Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark

[35] Univ Manitoba, Winnipeg, MB, Canada

[36] NYU, Hosp Joint Dis, New York, NY USA

[37] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada

来源：

ARTHRITIS CARE & RESEARCH | 2022年 / 74卷 / 04期

基金：

加拿大健康研究院; 英国惠康基金;

关键词：

DEFICIT ACCUMULATION; RELATIVE FITNESS; DAMAGE INDEX; RISK-FACTORS; COSTS; MORTALITY; PEOPLE; LIFE;

D O I：

10.1002/acr.24504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Methods Baseline SLICC-FI scores were calculated. The number and duration of inpatient hospitalizations during follow-up were recorded. Negative binomial regression was used to estimate the association between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. Linear regression was used to estimate the association of baseline SLICC-FI scores with the proportion of follow-up time spent in the hospital. Multivariable models were adjusted for relevant baseline characteristics. Results The 1,549 patients with SLE eligible for this analysis were mostly female (88.7%), with a mean +/- SD age of 35.7 +/- 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5) at baseline. Mean +/- SD baseline SLICC-FI was 0.17 +/- 0.08. During mean +/- SD follow-up of 7.2 +/- 3.7 years, 614 patients (39.6%) experienced 1,570 hospitalizations. Higher baseline SLICC-FI values (per 0.05 increment) were associated with more frequent hospitalizations during follow-up, with an incidence rate ratio of 1.21 (95% confidence interval [95% CI] 1.13-1.30) after adjustment for baseline age, sex, glucocorticoid use, immunosuppressive use, ethnicity/location, SLE Disease Activity Index 2000 score, SLICC/American College of Rheumatology Damage Index score, and disease duration. Among patients with >= 1 hospitalization, higher baseline SLICC-FI values predicted a greater proportion of follow-up time spent hospitalized (relative rate 1.09 [95% CI 1.02-1.16]). Conclusion The SLICC-FI predicts future hospitalizations among incident SLE patients, further supporting the SLICC-FI as a valid health measure in SLE.

引用

页码：638 / 647

页数：10

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